Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis. Immunol Cell Biol. 1999; 77: 58-63.Colussi, P.A. and Kumar, S. (1999) Targeted disruption of caspase genes in mice: what they tell us about the functions of ...
aThe alternations in levels of mRNA expression of Beclin-1, Bcl-xl, Bcl-2 and caspase-9 genes of striatum and substantia nigra exposed to ATR at different concentrations for 3 months are presented in Fig.4 (A). 叠更在Beclin-1、Bclxl、Bcl-2和caspase-9 striatum和substantia老黑基因mRNA表示...
Liver fat storage, also called hepatic steatosis, is increasingly common and represents a very frequent diagnosis in the medical field. Excess fat is not without consequences. In fact, hepatic steatosis contributes to the progression toward liver fibrosis. There are two main types of fatty liver di...
MG-132 subunit PI31 antibody Among the class 1 PI3Ks in two grasses, class 1A PI3Ks are heterodimers composed of catalytic pllO subunits (a, 13, S isoforms), which are structurally related to regulatory subunit (can be p85a, p55a, p50a, p85P or p55Y). Class IB has a family member...
Necrosis, long consid- ered a form of caspase-independent cell death (CID), or "acci- dental" cell death, is the pathological process that occurs when cells are exposed to an extreme physical or chemical insult or any other serious disruption to their normal physiology[35]. It is ...
Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 recep... Flaviviruses, particularly (JEV) and (), are important causes of virus-induced central nervous system () disease in . We used microarray analys...
Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in the Han:SPRD rat model of PKD. Thus, there is evidence that both epithelial cell apoptosis and proliferation are dysregulated in ADPKD and may represent a general mechanism for cyst growth. 展开 ...
An enzymatically inactive Caspase 8 homolog called cFLIP tightly regulates this deadly cellular mechanism by integrating into the DISC and inhibiting the caspase activation [10]. The mouse Fas mutations are recessive since heterozygous animals remain asymptomatic. The same is true for the FasL mutation...
NLR family proteins share typical tripartite domain structure: a C-terminal ligand recognition domain (LRR), a central NOD domain with ATPase activity involved in self-oligomerization and a N-terminus comprised of protein–protein interaction domains, such as caspase recruitment domains (CARDs) or ...
Genes encoding pro-inflammatory cytokines such as (TNF-⍺, IL-6, IL-8) and interferons (IFNs) are activated. Furthermore, the recognition of a strict relationship between coagulation and innate immunity, the term “immunothrombosis” has been introduced in clinical practice. Its activation in ...