Vesicluar transport of proteins from endosomes to the trans-Golgi network (TGN) is an essential cellular pathway, but much of its machinery is still unknown. A screen for genes involved in endosome-to-TGN trafficking produced two hits, the adaptor protei
Thus, EYA proteins have distinct functions: in nucleus they are involved in DNA damage repair10 and regulation in transcription4, in cytoplasm they appear to play a role in cell polarity, cell motility14,15 and innate immunity3. The EYA substrates - H2AX and ERβ – illustrate the role of...