北京时间农历正月初一凌晨,军事医学研究院生物工程研究所叶棋浓课题组在Cancer Cell杂志上以Articles的形式发表了题为“Transcriptional Regulation of the Warburg Effect in Cancer bySIX1”的研究论文,该研究发现SIX1是一个新的调控Warburg效应的关键转录因子,SIX1调控糖酵解的功能够直接被miR-548a-3p抑制,首次将miR-...
近日,叶江滨实验室在Cancer Research上发表了题为Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma的文章,发现线粒体解偶联剂可促进肿瘤表观遗传组重构和诱导肿瘤分化。 百年以前,德国生理学家、诺贝尔奖得主奥托.H.瓦博格 (Otto H. Warburg) 发现并以他的名字命名...
近日,叶江滨实验室在Cancer Research上发表了题为Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma的文章,发现线粒体解偶联剂可促进肿瘤表观遗传组重构和诱导肿瘤分化。 百年以前,德国生理学家、诺...
Furthermore, Warburg's work helped to show the potential for beneficial pharmaceuticals that could be developed by inhibiting certain chemical mechanisms of glycolysis to specifically target and kill cancer cells. This review covers research that has used the Warburg effect as a premise and the ...
未来的工作无疑将确定这些代谢改变如何在特定的致癌突变的背景下创造治疗干预的机会。(生物谷Bioon.com) 参考文献 Aaron M. Hosios et al. Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect. Cancer Res 2021 Oct 1;81(19):4896-4898. doi: 10.1158/0008-5472.CAN-21-2647....
北京时间农历正月初一凌晨,军事医学研究院生物工程研究所叶棋浓课题组在Cancer Cell杂志上以Articles的形式发表了题为“Transcriptional Regulation of the Warburg Effect in Cancer by SIX1”的研究论文,该研究发现SIX1是一个新的调控Warburg效应的关键转录因子,SIX1调控糖酵解的功能够直接被miR-548a-3p抑制,首次将miR...
The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression Cancer cells and fermenting yeast share several metabolic features.The induction of the Crabtree and the Warburg effect is similar in both cell types.Yeast... R Diaz-Ruiz,M Rigoulet...
It is a longstanding debate whether cancer is one disease or a set of very diverse diseases. The goal of this paper is to suggest strongly that most of (if not all) the hallmarks of cancer could be the consequence of the Warburgs effect. As a result of the metabolic impairment of the...
Gogvadze V, Zhivotovsky B, Orrenius S (2010) The Warburg effect and mitochondrial stability in cancer cells.Mol. Aspects Med.31(1), 60–74. Lunt SY, Vander Heiden MG (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.Annu. Rev. Cell Dev. Biol.27, 441...
named after the discoverer, the Warburg effect [8], and the last 10 years have seen a renewed interest and increasingly vigorous research into cancer cell metabolism. The aim was not only to understand the basics governing the Warburg effect, but also to comprehend the purpose of such a metab...