CAS号:273404-37-8分子式:C24H33ClN4O6分子量:509纯度:≥99%(HPLC) 靶标:Caspase-1:0.8nM(Ki),Caspase-4<0.6nM(Ki) 组分 规格 VX-765 2mg 说明书 1份保存:-20℃,有效期6个月。相关搜索:VX-765(Caspase 1抑制剂),Belnacasan,VX-765,Caspase 1抑制剂,Caspase 1 Inhibitors,273404-37-8...
生化机理Belnacasan (VX-765) 是一种强效的 Caspase-1 选择性抑制剂,在无细胞试验中的Ki值为 0.8 nM。第二阶段 储存温度-80℃储存 运输条件超低温冰袋运输 产品介绍 Information Belnacasan (VX-765) is a potent and selective inhibitor ofcaspase-1withKiof 0.8 nM in a cell-free assay. Phase 2. ...
VX-765,高效的Caspase-1/4抑制剂,2022年湖北医药学院人民医院,刘瑶等人以Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis(caspase1 抑制剂VX765通过促进线粒体自噬和胞吐作用抑制NLRP3炎症小体组装和动脉粥样硬化的新...
无论如何,将 VX765 等药物与抗逆转录病毒药物结合使用可能会改善 HIV 感染者的长期结果。 参考论文:The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load, and total HIV-1 DNA in ...
VX-765 is an orally absorbed prodrug of VRT-043198, a potent and selective inhibitor of caspases belonging to the ICE/caspase-1 subfamily. VX-765 is converted to VRT-043198 under the action of plasma and liver esterases. The active metabolite of VX-765 e
VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18. 温馨提示:VX-765 (Belnacasan),品质稳定,纯度>98+%,仅供实验使用.产品质量严格控制,保证品质。 关键字:VX-765,Belnacasan ...
Taken together, these data show that the caspase-1 inhibitor VX765 upregulates Cx43 expression and improves cell-to-cell communication in rat heart after MI via suppressing the IL-1尾/p38 MAPK pathway.doi:10.1038/s41401-021-00845-8Xue-ling Su...
参考论文:The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice . doi.org/10.7554/eLife.83207 Abstract HIV-1 infection results in the activation of inflammasome that may facilitate viral spread an...
VX-765_Apoptosis_Caspase_CAS号273404-37-8说明书_AbMole中国
Belnacasan (VX-765)是一种有效的选择性caspase-1抑制剂,无细胞试验中Ki为0.8 nM。 Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-...