Immunohistochemical Analysis of in Vivo Patterns of Expression of CPP32 (Caspase-3), a Cell Death Protease prostatic secretory epithelial cells, uterine endometrium and myometrium, mammary ductal epithelial cells, and the gastrointestinal epithelium of the stomach, inte... M Krajewska,HG Wang,S Krajew...
Here we identified Kunitz-type protease inhibitor TFPI2 as a critical factor connecting these cell populations and their associated GBM hallmarks of stemness and immunosuppression. TFPI2 promotes GSC self-renewal and tumor growth via activation of the c-Jun N-terminal kinase–signal transducer and ...
(2025). Neurotensin receptor agonist PD149163 modulates LPS-induced enterocyte apoptosis by downregulating TNFR pathway and executioner caspase 3 in endotoxemic mice: Insights from in vivo and in silico study. Naunyn-Schmiedeberg’s Arch Pharmacol. https://doi.org/10.1007/s00210-025-03794-9 Zhang,...
(Kim et al., 2014b). In contrast, irrespectively of diameter size, silica particles induce caspase-1 activation in macrophages (Kusaka et al., 2014). Other effects of silica NPs include ROS generation, the production of IL-6, IL-8, MCP-1, TNF-α, IL-1β, and the enhanced expression...
Pharmacovigilance analysis of immune checkpoint inhibitor-related reproductive adverse effects based on the FDA adverse event reporting system Bahadır Köylü , Buğra Han Esen & Fatih Selçukbiricik Article 04 March 2025 | Open Access Evaluation of ovarian functions in girls treated for he...
activating caspase-3 thereby reducing the anti-apoptotic protein Bcl-2 and MAP kinase activities[98]. Indeed, Bcl-2 dephosphorylation and intracellular levels are also modulated by P125A-endostatin in HUVEC[24]. Finally, interfering with the autophagic response by knocking down Beclin 1 dramatically ...
The expression of the active forms of p73 colocalizes with c-Abl and active caspase 3 in Purkinje cells. The inhibition of c-Abl with imatinib mesylate, an FDA-approved drug for treating chronic myelogenous leukemia, improves locomotor behaviors, reduces weight loss and neuronal apoptosis, and ...
In HSV-1– infected WT mice, the frequencies of pDCs fell more than two- fold and those pDCs remaining expressed more PDC-TREM on the cell surface than pDCs from control mice (Fig. 2 A). Using a pan-caspase inhibitor that is an in situ marker for apoptosis, we f...
alternatively polarized state that is more permissive to the bacteria [247]. IFN-Is can also mediate NLRP3 inflammation during gram-negative bacterial infection by the activation of caspase-11, leading to the production of proinflammatory cytokines IL-1β and IL-18, and inducing cell pyroptosis [...
Genetic inactivation of IL-1R1 or caspase 1, a key enzyme in IL-1β processing, reduced tumorigenesis in a two-step skin cancer model (Drexler et al., 2012). Inactivation of IL-1α and MyD88 reduces liver carcinogenesis in DEN model (Sakurai et al., 2008). Blocking IL-1 signaling ...