图7:NAc–VTA环路的双相调控可以模拟或逆转CES诱导的焦虑样行为。 当使用上述光遗传方法时,由于动作电位会反向传递到NAc神经元胞体,可能会导致其他的NAc神经元末端也参与诱发了焦虑。为了避免这种情况并使结论更加可信,研究人员将AAV2/1-...
中脑边缘脑区腹侧被盖区(VTA)是产生DA的神经元所在的主要区域之一。前人研究显示VTA DA神经元释放的DA靶向多个中脑皮质边缘脑区以调节情绪,包括内侧前额叶皮质(mPFC)、伏隔核(NAc)和杏仁核。研究表明激活mPFC表达D1受体的锥体神经元产生快速而持久的抗抑郁和抗焦虑反应。除了调控下游脑区之外,VTA DA神经元也可以在...
着NAc外,还支配着前额叶皮层(mPFC),杏仁核,海马等其他脑区.VTA-NAc奖赏环路在镇痛中发挥着重要作用,其可能是各种镇痛药发挥治疗作用的关键环路.然而目前关于VTA-NAc奖赏环路参与镇痛作用的研究多集中在急性热痛和急性炎性痛模型,对于其是否参与慢性的炎性痛和慢性神经病理性疼痛有待于进一步研究.各种药物在VTA-NAc...
是脑内富含多巴胺能神经元的三个脑区之一(其他两个脑区是黑质网状部和结节漏斗部),其他30%的神经元主要是GABA能神经元以及少量的谷氨酸能神经元.VTA的多巴胺能神经元除了支配着NAc外,还支配着前额叶皮层(mPFC)、杏仁核、海马等其他脑区.VTA-NAc奖赏环路在镇痛中发挥着重要作用,其可能是各种镇痛药发挥治疗作用的...
accumbens (NAc), lateral habenula (LHb), amygdala, and medial prefrontal cortex (mPFC). The normalized terminal intensity of the ensembles indicated that Mor-Ens terminals were more abundant in the NAc, while they showed no difference in the LHb, mPFC and amygdala compared with that of the Sa...
Thus, VTA neurons receiving DRN inputs preferentially project to the NAc but not the mPFC. To anatomically establish the VGluT3DRN → DAVTA→NAcMed pathway, we used a cell-type-specific tracing the relationship between input and output (cTRIO) system33,34 by injecting AAV-retro-DIO-Flp ...
It was found that the DREADD activation of VTA neurons involved in mesolimbic or mesocortical pathways, respectively, induced significant BOLD responses in DREADD-expressing regions and in the neural circuit without DREADD expression, such as Amygdala, NAcc, mPFC, ventral Pallidum (VP), TH and ...
mitochondrial respiration in the NAc in the social rank attainment in rats.4In addition, we show that along with the facilitation of social dominance in high-anxious rats, systemic diazepam treatment selectively increases mitochondrial respiration in the NAc, but not in the BLA or mPFC. This is ...
It was found that the DREADD activation of VTA neurons involved in mesolimbic or mesocortical pathways, respectively, induced significant BOLD responses in DREADD-expressing regions and in the neural circuit without DREADD expression, such as Amygdala, NAcc, mPFC, ventral Pallidum (VP), TH and ...
伏隔核(Nucleus accumbens, NAc)是成瘾性药物的主要调控脑区,由95%的GABA能中间棘神经元(medium spiny neurons, MSNs)组成,因表达不同的D1和D2多巴胺受体分为D1+和D2+... 王丽 - 《复旦大学》 被引量: 0发表: 2014年 甲基苯丙胺成瘾的表观遗传学机制 甲基苯丙胺成瘾与额前叶皮质(mPFC),中脑腹侧被盖...