最近,研究人员提出了非侵入性聚焦超声(FUS)靶向刺激腹侧被盖区(VTA)可调节VTA-mPFC通路活性,提高mPFC的多巴胺浓度,改善抑郁模型小鼠抑郁样行为,该研究为聚焦超声刺激应用于抑郁症临床治疗提供了理论依据和支撑。 送TA礼物 来自Android客户端1楼2024-08-06 23:01回复 ...
进一步为探究聚焦超声调控抑郁样行为的作用机制,研究者借助多巴胺探针实时记录超声刺激期间VTA下游内侧前额叶皮层(mPFC)的多巴胺浓度,结果显示该刺激策略能够提高mPFC 多巴胺浓度。随后,研究者探究了抑郁相关行为任务诱发的多巴胺浓度变化,发现对照组...
VTA-mPFC circuitmTORDepression is a common non-motor symptom in patients with Parkinson's disease (PD) and difficult to treat. Crocin is a natural multipotential neuroprotective compound that has been shown to elicit antidepressant activity and is promising for the therapy of neuropsychological ...
“Ultrasound Stimulation Attenuates CRS-Induced Depressive Behavior by Modulating Dopamine Release in the Prefrontal Cortex”文章,提出了非侵入性聚焦超声(FUS)靶向刺激腹侧被盖区(VTA)可调节VTA-mPFC通路活性,提高mPFC的多巴胺浓度,改善抑郁模型小鼠抑郁样行为,该研究为聚焦超声刺激应用于抑郁症临床治疗提供了理论...
(mPFC) neurons projecting to VTA-DA neurons but does not on those from glutamatergic terminals of the lateral hypothalamus (LH) neurons projecting to VTA-DA neurons; 2) different response of glutamatergic neurons projecting to VTA-DA neurons from the mPFC or the LH to morphine is related to ...
The present study intended to investigate whether the activation of cannabinoid CB1 receptors of the ventral tegmental area (VTA), the central amygdala (CeA) and the medial prefrontal cortex (mPFC) could induce conditioned place preference or aversion (CPP or CPA) in adult male Wistar rats. The...
Representative scheme showing the main corticolimbic connections between the mPFC and VTA.Laura, DazziGiuseppe, TalaniFrancesca, BiggioCinzia, UtzeriValeria, LallaiValentina, LicheriStefano, LutzuMaria, Cristina MostallinoPietro, Paolo SecciGiovanni, Biggio...
Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male miceCOCAINEDOPAMINERGIC neuronsCOCAINE-induced disordersCOCAINE abuseCOMPULSIVE behaviorPREFRONTAL cortexMICEAs a central part of the mammalian brain, the prefrontal cortex (PFC) has been ...
Effects of the systemic administration of SR141716 in fed ad libitum and FR rats on mPFC and VTA neurons excitability and inhibitory activity of WIN 55212-2 and baclofen on sIPSC frequ...