Furthermore, increased expression of cAMP responsive genes was compromised in cells resisting VP16CREB-mediated differentiation. CONCLUSION: A constitutively active CREB induces terminal differentiation in a subset of NBP2 cell population. Altered expression of cAMP responsive genes may account for ...
This VP16-CREB-mediated L-LTP differs from the conventional late phase of LTP in not being dependent on new transcription. This finding suggests that in the transgenic mice the mRNA transcript(s) encoding the protein(s) necessary for this form of L-LTP might already be present in CA1 ...
VP16-CREB fusion geneThe present application describes a cell that has integrated into its genome fusion molecule V16-CREB.Sung Ho Hahm
VP16-CREB fusion geneThe present application describes a cell that has integrated into its genome fusion molecule V16-CREB.Hahm, Sung Ho
VP16-CREB FUSION GENEThe present invention relates to a vp-creb fusion gene stably and efficiently expressing a transgene in a cell, and to a use of the same.HAHM, SUNG HO
Expression of VP16-CREB, a constitutively active form of CREB, in hippocampal neurons of the CA1 region lowers the threshold for eliciting the late, persistent phase of long-term potentiation (L-LTP) in the Schaffer collateral pathway. This VP16-CREB-mediated L-LTP differs from the ...
Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture. Neuron 2005; 48: 123-37.Barco A, Patterson S, Alarcon JM, Gromova P, Mata-Roig M, Morozov A et al (2005). Gene expression profiling of...
Rather, VP16 interacted with the CREB binding protein (CBP) coactivator and efficiently inhibited the formation of the transcriptional complexes IRF-3-CBP in the context of HSV-1 infection. These results illustrate that VP16 is able to block the production of IFN-尾 by inhibiting NF-kB ...
Like other members of the CREB/ATF family, it may play an important ro...