网络电压门控钠离子通道;电压门控钠通道 网络释义 1. 电压门控钠离子通道 电压门控钠离子通道(voltage-gated sodium channels)是可兴奋细胞产生电兴奋的基础结构,其α亚单位为基本功能单位,可… www.ebiotrade.com|基于 1 个网页 2. 电压门控钠通道 ...
Voltage-gated sodium channels are proteins found in mammalian neurons that are responsible for generating electrical signals known as action potentials. When the membrane of a neuron becomes depolarized, these channels briefly open, allowing sodium ions to enter the cell. Sodium channels are composed ...
Voltage-gated sodium channels (VGSCs) are transmembrane proteins that increase the permeability of sodium ions across membranes. The permeability of these channels depends on the voltage drop across the membrane. In a typical neuronal action potential, VGSCs remain closed until the membrane potential ...
Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in neurons and other cells. VGSC modulators have their origins in empirical pharmacology and are being used as local anaesthetics, antiarrhythmics, analgesics and antiepileptics, and for ...
Voltage-gated sodium channels comprise a single family of nine related functional α-subunits which appear to have arisen by gene duplication 1. All sodium channel α-subunits consist of four homologous domains that form a single, voltage-gated aqueous pore. The α-subunits are >75% identical ov...
www.nature.com/scientificreports OPEN The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels received: 24 May 2016 accepted: 19 December 2016 Published: 24 January 2017 Christina Valkova1, Lutz Liebmann2, Andreas Krämer1, Christian A. Hübner2 & ...
Voltage-gated sodium channels (NaV) are responsible for the rapid depolarization of many excitable cells. They readily inactivate, a process where currents diminish after milliseconds of channel opening. They are also targets for a multitude of disease-causing mutations, many of which have been shown...
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (NaV) channels. This molecular adaptation enables these cells to produce action potentials, and is essential to their function. With the advent of the molecular...
Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in metastatic cells from a number of cancers. In these cells, Na+ current carried by α subunits enhances migration, invasion...