In-vivo activity of compound 2. Passive avoidance task. The first behavioral test performed was the passive avoidance (PA) task, which allows the evaluation of the effects of a drug on fear-motivated contextual memory. This is one of the most frequently used behavioral methods to ...
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N = 3 independent experiments per time point. (b) Immunoprecipitation experiments to examine a potential direct interaction of ATF6 with SIK1. Upper panel: Experimental workflow. HEK cells were transfected with a Myc-Flag-SIK1 plasmid and treated with DMSO or HG for 6 h. After ...
In-vivo activity of compound 2. Passive avoidance task. The first behavioral test performed was the passive avoidance (PA) task, which allows the evaluation of the effects of a drug on fear-motivated contextual memory. This is one of the most frequently used behavioral methods to ...
(set to 1) for the low dose at 2 weeks for each reprogramming factor. Each point represents a single mouse. Center values are means and error bars are S.D. Statistical analyses were performed by one-way ANOVA with Tukey’s Multiple Comparison Test. *,p < 0.05; **,p < 0.01...
The point mutations, Rab27aT23N, Rab27aN133I, Rab27aQ78L, Rab27bT23N and Rab27bN133I were generated by PCR mutagenesis using the rat Rab27a or the human Rab27b cDNA as a template. The myc-epitope was inserted in frame into the Rab27 cDNA by subcloning the Rab27 cDNA into ...
Toward this end, we first embedded light-emitting diode (LED, ROHM Semiconductor) strips into the textile channels for a washability test. LED brightness with a supply voltage of 2 V and interconnect resistance were unchanged after the first wash until up to ten wash cycles (Supplementary ...
From an imaging point of view, the whole fingernail in vivo 3D imaging with a large scan area, and without any motion artifact was challenging. Figure6shows the 3D images of control, with nail-art, and art removed nail 3D images without any motion artifact, thus, the quantitative assessment...
possibly due to the lower number of bacteria in the samples at that time-point. At 48 hours, only limited difference was detected between the transcription level of the gene in the infectious samples and the in vitro cultures. Furthermore, the mean fold change in gene expression in the liver...
A representative monolayer growth experiment from n ¼ 3 is shown; three samples were analyzed for each time point per experimental series. (c) Spheroids derived from 1500 CD133 þ HT29 cells are significantly larger at day 4 in liquid overlay culture than those originated from the same ...