IV to Oral Vitamin D Switch BeneficialThe article reports on a study by Canadian researchers which found that switching from intravenous (IV) to oral activated vitamin D drug may offer similar control of secondar...
Vitamin K is essential for several physiological processes, such as blood coagulation, in which it serves as a cofactor for the conversion of peptide-bound glutamate to γ-carboxyglutamate in vitamin K-dependent proteins. This process is driven by the vitamin K cycle facilitated by γ-carboxyglutam...
Interestingly, although VKORC1L1 carries out the same two enzymatic steps of the vitamin K cycle as does VKORC1, it appears to be far less sensitive to oral anticoagulant drugs, suggesting that its biological activity may not be substantially reduced when oral anticoagulants ...
by preventing the dissimilitude of B-cell precursors into plasma cells. CD4 T cells can transform into regulatory (Treg) and suppressor T cells as well as Th1 and Th2 cells. Active vitamin D increases the conversion of CD4 T cells into Treg cells. In cases where there exists no vitamin D...
“An IV protocol has been shown to dramatically improve chances of survival in septic patients. Giving adult patients 200 mg of thiamine every 12 hours, 1,500 mg of ascorbic acid every six hours, and 50 mg of hydrocortisone every six hours for two days reduced mortality from 40% to 8.5%...
Of the metabolites identified to date, the dihydroxylated derivative 1,25(OH)2D has the most potent effect on calcium transport. The first hydroxylation to yield 25-hydroxyvitamin D (25-OHD) occurs in the liver. The conversion is catalyzed by a specific microsomal enzyme, vitamin D-25-...
thermosensitiveisomerizationtovitamin D3(Bikle, 2014). Most of thevitamin Dneeded for cellular functions is obtained by natural sunlight conversion or by oral vitamin D supplementation (Wolf, 2019;Young et al., 2019).Vitamin D receptor(VDR) is expressed ubiquitously. Roughly 5% of thehuman ...
Vitamin D is the collective term for a group of compounds formed by the action of ultraviolet irradiation on sterols. Cholecalciferol (vitamin D3) and calciferol (vitamin D2) are formed by irradiation of the provitamins 7- dehydrocholesterol and ergosterol, respectively. The conversion to vitamin...
Check access to the full text by signing in through your organization. Access through your organization Section snippets History The therapeutic efficacy of animal liver (via local application or oral ingestion) against blindness and keratomalacia has been known since antiquity. In 1913, McCollum ...
Potentially, inadequate vitamin C status in MetS contributes to small intestinal bacterial overgrowth, transcytosis of enteric bacteria, and an elevation of circulating LPS, which elicits a low-grade inflammatory response. By contrast, oral ingestion of large-dose vitamin C supplements results in limited...