In 1942, Link himself set up field trials to test the suitability of dicoumarol as a rat poison. Tests by O’Connor (1948) using a concentration of 0.44 mg/g were reported as highly successful. However, tests carried out by the U.S. Public Health Service (Hayes and Gaines,...
6.1. Osteocalcin Like all VKDP proteins, OC requires vitamin K for the γ-glutamylcarboxylation of three glutamate-residues, which in turn confers functional protein activity. In tissues and the circulation OC is present in both the carboxylated (cOC) and uncarboxylated (ucOC) conformations. OC ...