Warfarin may be the only compound for which a log time-log dosage curve with all three segments has been demonstrated experimentally; the 90-day LD50 in rats is only 0.077 mg/kg/day, and the chronicity index is 20.8. Rats tolerated for 300 days a daily dosage slightly greate...
Keywords: oral anticoagulants; vitamin K; vascular calcification; coumarin; DOACs 1. Arterial and Venous Thrombosis In 1856 Rudolf Virchow, often regarded as the founder of modern pathology, delineated three major components that were responsible for the formation of emboli in the venous circulation. ...