J.-K. Tie, D.W. Stafford, in Methods in Enzymology, 2017 3.1 Rationale VKOR is the enzyme that reduces KO in the vitamin K cycle (Fig. 1). It is the target of warfarin, the most widely used oral anticoagulant for prevention and treatment of thrombosis. However, achieving the desired...
It has been shown, in k.o. mice lacking the enzyme that is pivotal for the hydroxylation at position 1, that 25-hydroxycholecalciferol can bind to the vitamin D receptor, although with lower affinity in comparison to 1,25-dihydroxycholecalciferol. In addition, high concentrations of vitamin D...