This chapter focuses on vitamin D receptors and biologic responses. Vitamin D, along with the peptide hormones, parathyroid hormone (PTH) and calcitonin (CT), are three of the most important regulators of calcium and phosphorus metabolism. These substances work together to affect an efficient ...
Although VDRs have been identified on cell membranes, it isn’t currently known whether the more rapid, non-genomic action of vitamin D occurs through membrane-associated vitamin D receptors or a different cellular receptor.[15] Although the most commonly associated effects of vitamin D on the ...
Heterogeneous loss of function mutations in the vitamin D receptor (VDR) interfere with vitamin D signaling and cause hereditary vitamin D-resistant rickets (HVDRR). HVDRR is characterized by hypocalcemia, secondary hyperparathyroidism and severe early-onset rickets in infancy and is often associated ...
Some of the effects of vitamin D deficiency that will be discussed include the development of dementia caused by the increase of...关键词: Parkinson’ s disease and neurodegeneration, Vitamin D, Oxidative stress, Neuroinflammation, Vitamin D receptors DOI: 10.1186/s12974-018-1266-6 年份:...
pigments that can be converted to vitamin A in the body; of these pigments, beta-carotene(provitamin A) is an excellent source of vitamin activity. The existence of vitamin A was first clearly recognized in 1913, its chemical nature was established in 1933, and it was first synthesized in ...
Vitamin D forSeasonal Affective Disorder (SAD) Seasonal Affective Disorder (SAD)is a mood disorder characterized by depression that occurs during fall and winter months when sunlight levels are low. SAD typically coincides with a sudden drop in Vitamin D levels in the body. Several studies have ...
Vitamin D receptors are widely expressed throughout the body, and experimental evidence suggests that vitamin D has antineoplastic activity.21 The binding of vitamin D to the vitamin D receptor results in transcriptional activation and repression of target genes, producing apoptosis,21 antiproliferative ...
dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects o n breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and ...
展开 关键词: p62 sequestosome-1 hepatic stellate cells fibrosis hepatocellular carcinoma non-alcoholic steatohepatitis liver cancer nuclear receptors vitamin D receptor inflammation DOI: 10.1016/j.ccell.2016.09.004 被引量: 37 年份: 2016 收藏 引用 批量引用 报错 分享 全部...
Many epidemiological studies have highlighted the link between vitamin D deficiency and schizophrenia. In particular, two prominent studies report an association between neonatal vitamin D deficiency and an increased risk of schizophrenia. In parallel, m