This chapter describes research over the past two decades which has defined the fundamental genomic mechanism of action of the hormonal form of vitamin D. This research revealed that the actions of vitamin D are mediated by a nuclear receptor protein that binds 1,25-dihydroxyvitamin D with high ...
transcription activating function termed activation function-1 (AF-1) that interacts with thegeneral transcription factorIIB, aDNA bindingdomain (C) with twozinc fingers(exons 2, 3), a “hinge” region (D), and a longcarboxyl terminaldomain (E) with ligand andretinoid X receptorα (RXRα)...
Vitamin D receptor (VDR) mediates many genomic and non-genomic effects of vitamin D. Recently, the mitochondrial effects of vitamin D have been characterized in many cell types. In this article, we investigated the importance of VDR not only in mitochondrial activity and integrity but also in ...
Two nuclear receptors, VDR and farnesoid X receptor (FXR) interact with each other in a Vitamin D3-independent manner26. To verify the changes of VDR and related pathways in addition to microbiome and metabolites, we investigated the protein expression of VDR and FXR in mice with or without ...
BACKGROUND: The vitamin D receptor (VDR) is expressed in human testis, and vitamin D (VD) has been suggested to affect survival and function of mature spermatozoa. Indeed, VDR knockout mice and VD deficient rats show decreased sperm counts and low fertility. However, the cellular response to...
Mitochondrial function was assessed via reactive oxygen species (ROS) generation and changes in the mitochondrial membrane potential (ΔΨm). Our study demonstrated that vitamin D levels were significantly lower in 40 GDM patients. The silencing of the vitamin D receptor (VDR) decreased cell ...
Elimination of vitamin D receptor in vascular endothelial cells alters vascular function. Hypertension 64, 1290–1298 (2014). Article CAS PubMed Google Scholar Wong, M. S. et al. Vitamin D promotes vascular regeneration. Circulation 130, 976–986 (2014). Article CAS PubMed Google Scholar ...
Three-dimensional structure-function relationship of vitamin D and vitamin D receptor model 50. Deciphering the structure-function relationship of vitamin D receptor complexes by computational methods: CCOMP and MSITE programs Sicinska, Wanda, Dom... S Yamada,K Yamamoto,H Masuno,... 被引量: 0...
21Studies in other chronic conditions, such as diabetes, have implicated the vitamin D–vitamin D receptor (VDR) axis in the endothelial regenerative process.22,23,24In vitro, vitamin D improves CPC viability, migration, and colony-forming capacity by releasing vascular endothelial growth factor, ...
The breakdown of the intestinal barrier is a common manifestation of many diseases. Recent evidence suggests that vitamin D and its receptor VDR may regulate intestinal barrier function. Claudin-2 is a tight junction protein that mediates paracellular water transport in intestinal epithelia, rendering ...