In vitro and in vivo studies have provided understanding of an underlying mechanism for the vitamin D effect. However, recently there has been increased intensity in vitamin D/cancer research after publication of a randomized trial that found that vitamin D 3 and calcium reduced the risk of all...
Vitamin D exerts anti-cancer effects in recent clinical trials and preclinical models. The actions of vitamin D are primarily mediated through its hormonal form, 1,25-dihydroxyvitamin D (1,25(OH)2D). Previous literature describingin vitrostudies has predominantly focused on the anti-tumourigenic ...
Vitamin D receptor (VDR) expression is found across all these tumor types and differences between the level of expression and cancer grade/pathologic type have been identified with the need for further studies warranted. Anti-proliferative activities of vitamin D and its analogs are observed across ...
dysregulated in many types of cancer, conferring resistance to the antitumorigenic effects of vitamin D and thereby contributing to the development and progression of cancer. Thus, understanding dysregulated vitamin D metabolism and function in cancer will be critical for the development of promising new...
Considerable epidemiological evidence suggests that high levels of circulating vitamin D (VD) are associated with a decreased incidence and increased survival from cancer, i.e., VD may possess anti-cancer properties. The aim of this investigation was therefore to investigate the anti-cancer potential...
Preclinical and epidemiological evidence suggests that vitamin D may have anti-cancer activities in patients with colorectal cancer. A recently completed, randomised Phase 2 trial of vitamin D3 supplementation in patients with metastatic colorectal cance
to bottom versus top third of baseline 25-hydroxyvitamin D levels found higher relative risks for those with cancer at time of enrolment than those without.1 The implication of this finding is that vitamin D has a much stronger impact on survival after developing cancer than on reducing the …...
Vitamin D may have anti-skin cancer effects, but population-based evidence is lacking. We therefore assessed associations between vitamin D status and skin cancer risk in an Australian subtropical community We analyzed prospective skin cancer incidence for 11 years following baseline assessment of serum...
a meta-analysis Y Kim1 and Y Je*,1 1Department of Food and Nutrition, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, South Korea Background: Experimental studies suggest potential anti-carcinogenic properties of vitamin D against breast cancer risk, but the epidemiological evidence...
R. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diabetes Endocrinol. 2, 307–320 (2014). Article CAS PubMed Google Scholar Kanis, J. A. et al. European guidance for the diagnosis and management of osteoporosis...