Large randomized controlled trials designed to address specific oncology-relevant endpoints are warranted to define optimal vitamin D level(s) in oncology. ■Kathleen M. Wesaand Barrie R. CassilethNew York
For the past 20 years it has been consistently reported and well established that the active metabolite of vitamin D, 1,25(OH)2D3 exhibits potent cell differentiating property in leukemia cells as well as much cancer cells [13], [14]. The antiproliferative and differentiation-inducing effects ...
Vitamin D system is a complex pathway that includes precursors, active metabolites, enzymes, and receptors. This complex system actives several molecular pathways and mediates a multitude of functions. In addition to the classical role in calcium and bone homeostasis, vitamin D plays “non-calcemic...
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The past year has produced stunning research findings concerning vitamin D's potential role in preventing and perhaps even treating cancer.
Vitamin D, a fat-soluble prohormone is synthesized in response to sunlight. Experimental evidence suggests that vitamin D may reduce the risk of cancer through regulation of cellular proliferation and differentiation as well as inhibition of angiogenesis
between 25 (OH) D and breast cancer in both cohort studies (RR = 0.85, 95%CI:0.74–0.98) and case-control studies (OR = 0.65, 95%CI: 0.56–0.76). However, analyzing by menopausal status, the protective vitamin D – breast cancer association persisted only in the premenopausal ...
Over the last several decades, extensive research on vitamin D and its role on cancer incidence, cancer survival (survival or mortality from cancer among individuals diagnosed with cancer), and cancer mortality (fatal cases occurring during the study period in an initially cancer-free population) ...
CedricF.Garland,FrankC.Garland,SharifB.Mohr,EdwardD.Gorham 摘要: Higher levels of the principal circulating form of vitamin D, 25-hydroxyvitamin D [25(OH)D], are associated with substantially lower incidence and death rates from colon, breast, and ovarian cancer, with a linear dose–response ...
Despite extensive epidemiological research and plausible biological mechanisms being elucidated, it is unclear whether vitamin D reduces risks of cancer incidence and mortality. Only for colorectal cancer does the observational evidence seem persuasive, whereas for other cancer types an anti-carcinogenic role...