Hormone molecular biology and clinical investigationChirumbolo S. Vitamin D3 in cancer prevention and therapy: the nu- tritional issue. Horm Mol Biol Clin Investig 2015;23:71-8.A. Chirumbolo, "Vitamin D3 in cancer prevention and therapy: the nutritional issue," Hormone Molecular Biology and ...
A low serum level of vitamin D has been associated with an increased incidence of gastrointestinal tract cancers. However, the effects of vitamin D3 have not been investigated in gastric cancer and cholangiocarcinoma. In the present study, we found that vitamin D3 treatment significantly suppressed...
Cancer cells, including breast, have high glycolysis rates to meet their energy demands for survival and growth. Vitamin D-3 (VD3) is important for many important physiological processes such as bone mineralization, but its anticancer role is yet to be proven. We find that VD3 treatment ...
Vitamin D 3 intake and sunlight exposure have a protective effect against colorectal cancer (CRC) and other neoplasias. In line with epidemiological data, the most active metabolite of vitamin D 3 ,1α, 25-dihydroxyvitamin D 3 , [1α,25(OH) 2 D 3 ] has antiproliferative, prodifferentiation...
agents could be used at concentrations well below their maximal tolerated doses.Tumor cells derived from a variety of different sources have been shown to express the Vitamin D3 receptor and to be susceptible to growth arrest and / or cell death in response to Vitamin D3 and its analogues. ...
Vitamin D3 selectively suppresses RelB to enhance radiation sensitivity of prostate cancer 来自 aacrmeetingabstracts.org 喜欢 0 阅读量: 45 作者:Y Xu,F Fang,S Josson,K Daret 摘要: The nuclear factor-kappaB (NF-κB) protein, RelB, is uniquely expressed at a high level in prostate cancer ...
dose adjunctive agents, including vitamin D3 to senstitise cells to mild freezing thereby increasing cancer destruction.This study describes a molecular basis of Vitamin D3 cryosensitization including the response and efficacy of the combination in both androgen-sensitive and insensitive prostate cancer....
They are classified into five forms [2]; vitamin D2, ergosterol; D3, cholecalciferol; D4, 22,23 dihydroergoalciferol; D5 sitosterol (24-ethylcholecalciferol) and D6 stigmasterol (Fig. 1). Vitamin D is derived from a cholesterol-like precursor, 7-dehydrocholesterol. When human skin is ...
Epidemiological studies have demonstrated that vitamin D status is inversely associated with breast cancer incidence, mortality, and recurrences, suggesting vitamin D as a potent agent to reduce the risk of breast cancer. The hormonally active metabolite
Apoptosis rate was higher than that of control group and tumor cells were arrested in G0/G1 phase, especially those treated with vitamin D3 and tamoxifen. ConclusionsVitamin D3 could significantly induce apoptosis of breast cancer cells and arrest tumor cells in G0/G1 phase. It is synergic ...