Vitamin D (VitD) is a hormone naturally produced by mammalian cells in a coordinated manner by the skin, liver, and kidneys. VitD deficiency or insufficiency is prevalent in patients with CKD, and serum levels of VitD are inversely correlated with the degree of kidney ...
which is converted to previtamin D3 on exposure to UVB (wavelength 270-300nm). Another process changes this into cholecalciferol before it undergoes activation in the liver and kidneys to become active vitamin D. Active vitamin D is called 1,25 dihydroxyvitamin D3 (1,25(OH)D) or calcitriol...
Conversely, 1,25(OH)D only lasts for a few hours in the body and levels are a thousand-fold less than those of 25(OH)D. Our body also has a way of increasing the production of active D3 by the kidneys during times of deficiency and insufficiency, so a blood test for 1,25(OH)D...
The livers and kidneys from adult beagle dogs chronically exposed to 1,1,1-trichloro-2,2-bis(-chlorophenyl)ethane (DDT) and from their Fweanling progeny were analyzed for vitamin A content. The dogs, subjects of a multigeneration study of the effects of DDT on canine reproduction, were fed...
The ultraviolet light in sunshine makes a type of cholesterol that is found just under the skin, into cholecalciferol (or vitamin D3). The vitamin D3 gets carried to the kidneys, where it becomes even more active. Some of the vitamin D stays in the liver and kidneys, where it helps to...
(OH)2D3, is generated from its precursor, cholecalciferol, by a series ofhydroxylationsteps and released from the kidneys[113]. 1,25(OH)2D3binds tovitamin D receptorsand thereby activates several transcription factors. The regulatory effects of thevitamin D response elementandbinding siteson genes...
The vitamin D hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is generated by a series of hydroxylation steps in the liver and kidneys. We investigated whether naturally vitamin D-deficient subterranean mammals (naked mole rats, Heterocephalus glaber) employ the same enzymatic pathways, and wheth...
Calbindin D9k (CB9k) and D28k (CB28k) are intracellular soluble calcium-binding proteins, whose expressions are considered to be regulated by vitamin D. However, the amount of CB28k expression in the kidneys of vitamin D receptor-null mice was reported to be similar to that in wild type...
Vitamin D3(cholecalciferol) is synthesized in the skin by transformation of 7-dehydrocholesterol exposed to ultraviolet B rays of the sun. Vitamin D binding protein transports D3to the liver, where it is hydroxylated to the inactive 25(OH)D form (calcidiol). In the kidneys, it is further...
Kidneys play an important role in converting Vitamin D into its active (usable) form. Is it true that Vitamin D cures psoriasis, prevents cancer, protects against dying from cardiovascular diseases, and improves cognitive function? We know that Vitamin D is involved in reducing inflammation, regula...