Vitamin D (VitD) is a hormone naturally produced by mammalian cells in a coordinated manner by the skin, liver, and kidneys. VitD deficiency or insufficiency is prevalent in patients with CKD, and serum levels of VitD are inversely correlated with the degree of kidney i...
Vitamin D is mainly stored in the liver but can also be found in the skin, brain, spleen, and bones. In the presence of parathyroid hormone vitamin D is converted in the kidneys into it active form (dihydroxycholecalciferol).Answer and Explanation: Vitamin D have a lot of functions and be...
First, the dynamic interactions between the parathyroids, kidneys, bone, and DBP determine the toxicity threshold for vitamin D, i.e., whether hypervitaminosis D is associated with actual toxicity. In the otherwise healthy individual, the dynamic interactions between the parathyroid gland, kidney, ...
Vitamin D3(cholecalciferol) is synthesized in the skin by transformation of 7-dehydrocholesterol exposed to ultraviolet B rays of the sun. Vitamin D binding protein transports D3to the liver, where it is hydroxylated to the inactive 25(OH)D form (calcidiol). In the kidneys, it is further...
Klotho is an anti-aging protein that is mostly secreted by the kidneys, the brain, and the thyroid. It plays a significant role in regulating kidney function and vascular health. Klotho gene is named after “the Spinner” (Clotho from Greek mythology), the goddess who spins the thread of ...
Vitamin Dis non-toxic. So is considered well-tolerated and safe. Side effects are rare but can include dry mouth, fatigue, headaches, metallic taste, nausea, sleepiness and vomiting. Doses of Vitamin D higher than 4,000 IU daily is possibly unsafe because it could cause excessive blood level...
Active vitamin D levels increase when you regularly eat a diet low in calcium. When elevated, the role of calcitriol begins in the intestine, where it promotes increased absorption of calcium in an effort to overcome your low dietary calcium intake. Calcitriol also influenc...
Calcium absorbed from intestinal canal can be transported through the blood circulation from the liver and kidneys to the bone and other calcified tissues, and excret from the bone to the kidneys. This transport mechanism is controlled by vitamin D. When the concentration of calcium, phosphorus ...
Due to old age and because the skin is not able to synthesize vitamin D efficiently, older adults are at a greater risk of developing a vitamin D deficiency. As people get older, their skin does not produce much vitamin D as a reaction to sun exposure. Simultaneously, their kidneys will ...
Cavalier 1 1Department of Clinical Chemistry, University of Liege, Liege, Belgium 2Fujirebio Europe N.V., Ghent, Belgium (Belgium) nathalie.le.bastard@fujirebio.com Background: Parathyroid hormone (PTH) influences calcium and phosphorous homeostasis directly through bones and kidneys. PTH ...