To test if the effect was due to the activated form of vitamin D (1α,25-hydroxy-vitamin D3, VD) cultures were exposed to the vitamin D precursor 7-dihydrocholesterol (7DHC). Exposure of 7DHC (10-11 –10-7M) per se didn’t affect neuronal survival (Fig. 2c). Addition of 7DHC...
12-diketolithocholate 3b-hydroxy-5-cholenoic acid Lithocholate 3-dehydrodeoxycholate Deoxycholate 0.0 0.4 0.8 1.2 1.6 FC ratio VDR Δlyz / VDRLoxP D Secondary bile acid metabolism in female Tauroursodeoxycholic acid sulfate (2) 3b-hydroxy-5-cholenoic acid 7-ketodeoxycholate Taurocholenate sulfate*...
A one way analysis of vari ance post hoc Tukey test was used to reveal signif icant differences between the groups for comparing the alveolar bone loss (ABL). The Kruskal–Wallis comparison test was used to determine differences between groups in the his topathological and immunohistochemical ...
In comparing the performance of holoTC with other markers of vitamin B-12 deficiency (n = 937), Hvas and Nexo (2005) concluded that holoTC shows promise as a first-line test for diagnosing early vitamin B-12 deficiency. Despite holoTC exhibits potential as a biomarker for early vitamin B...
D) < 30 ng/mL) and 32 (44.4%) had a serum level of (25(OH)vit. D) < 20 ng/mL. On gingival probing, GBI was >25 in forty patients and the OHI was unsatisfactory due to plaque, pigmentation, and calculus in twenty-seven women. With respect to the CPTIN score, fifty-nine ...
VD3is transported to the liver, where it is hydroxylated to 25-hydroxycholecalciferol (25-OH-D3) by 25-hydroxylase in the hepatocyte mitochondria [4]. Subsequently, in the proximal tubular epithelial cells of the kidney, 25-OH-D3is further converted to the active form, 1,25-dihydroxycholecal...
In this study, the first double blind, randomized control trial (RCT) conducted was designed to test the specific effect of a nutrient supplement (Lester's Oil®). This supplement, made in New Zealand (NZ) is a new generation, long chain omega-3 PUFA and vitamin D supplement that had ...
The Kruskal–Wallis ANOVA multiple comparison p-value (two-tailed) test and the Mann–Whitney U-test were used for tumor growth inhibition analysis. p-values less than 0.05 were considered as significant. 4. Conclusions In our study, we have demonstrated that vitamin D analogs augment the ...
top-50 DEGs. (D) STRING analysis depicting the networks of the top-50 DEGs. (E) qPCR validation of representative DEGs. (F) KEGG pathways of DEGs enriched in the VB12 versus PBS group. Bar graphs show mean ± SD. *p< 0.05, **p< 0.01, ***p< 0.001; two-tailed unpairedt-test (E...
Differences be- tween sample means were compared using one- or two-way analysis of variance (ANOVA) followed by Tukey's or Sidak's multiple comparison test, respectively, where a p-value of 0.05 was considered statistically significant. All analyses were performed in GraphPad Prism version 7.00....