cobalamin deficiency type C (MMACHC) patients (an inborn error in metabolism marked by inactivity of theMMACHCgene product) receiving a standard treatment of hydroxycobalamin, betaine, folate, and carnitine. Protein products ofME2,GLUD1, andGPD2, genes involved...
www.nature.com/scientificreports OPEN Vitamin D receptor promotes healthy microbial metabolites and microbiome Ishita Chatterjee1, Rong Lu1,Yongguo Zhang1, Jilei Zhang1,Yang Dai 2,Yinglin Xia1 ✉ & Jun Sun 1 ✉ Microbiota derived metabolites act as ...
DHA: Dehydroascorbate, ASC: Ascorbate, GLUT: Glucose Transporter, (H)TML(D): (Hydroxy) Trimethyllysine (Dioxygenase), CPT1: Carnitine Palmitoyltransferase 1, LCFA: Long-Chain Fatty Acids; LACS: Long-Chain Acyl-CoA Synthetase, TNFR: Tumor Necrosis Factor Receptor, NF-κB: Nuclear Factor Kappa-...
D51.0 Vitamin B12 deficiency anemia due to intrinsic factor deficiency [Pernicious anemia, Addisonian, Biermer] D51.1 -hyphen D51.9 Other Vitamin B12 deficiency anemias D52.0 Dietary folate deficiency anemia D53.1 Other megaloblastic anemias, not elsewhere classified D53.9 Nutritional anemia, unspecif...
(an inborn error in metabolism marked by inactivity of theMMACHCgene product) receiving a standard treatment of hydroxycobalamin, betaine, folate, and carnitine. Protein products ofME2,GLUD1, andGPD2, genes involved in anaplerosis and redox equivalent shuttling, are up-regulated while variant 2 ...
Vitamin D supplementation upregulates genes such as Ppara, Ppargc1a, Ppargc1b, Cpt1b, Acadm, and Acadl, which are involved in mitochondrial biogenesis and fatty acid oxidation [58]. Figure 2. Intracellular mechanism of action of vitamin D (created with Biorender.com). Another mechanism ...
= 0.035), and CPTIN = 3 (p < 0.004). Concerning the serum level of vitamin D, a statistically significant correlation was found between vitamin D deficiency (serum level of 25(OH)vit. D) < 30 ng/ml) and PCR>75% (p = 0.021), GBI>50% (p = 0.002), OHI>3 (p < 0.008), and...
In contrast, 5-hydroxyeicosatetraenonate, an arachidonic acid metabolite reported to increase intestinal epithelial paracellular permeability [38], and 2-deoxy-D-glucose, a glucose analogue that effectively inhibits glucose metabolism, were reduced in the VB12 culture (Figure 3C). The intracellular ta...
Keywords: vitamin D receptor; vitamin D; lithocholic acid; bile acid; CYP24A1; TRPV6; calcium metabolism; ileum 1. Introduction The vitamin D receptor (VDR) mediates the physiological functions of the active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], including calcium ...
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