In addition to the negative feedback regulation by calcitriol, vitamin D metabolism is also regulated by two hormones, parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23), both of which play major roles in maintaining calcium and phosphate homeostasis47,48,49. PTH is secreted by...
The second major determinant of vitamin D status is body weight. Until recently, it has been unclear whether low levels of vitamin D cause higher body weight or higher body weight causes low vitamin D status; however, recent studies have clar- ified that equivalent amounts of vitamin D are ...
and their contributions to unraveling vitamin-based regulation of protein expression and tissue function are explored. The current work is intended to provide background information to understand each vitamin’s (Figs.1and2) molecular functions and highlight...
However, inequitable distribution and poverty are major hindrances to adequate vitamin A. Preformed vitamin A, which is found in animal products and supplements, is efficiently absorbed and epidemiological studies suggest that chronic high intakes of preformed vitamin A are associated with hip fractures ...
Following ingestion it is absorbed in the small intestine and stored in the liver. Although it exists in multiple forms the major form of folate circulating in human blood is methyltetrahydrofolate. Two-thirds of serum folate is bound to proteins and at least half is bound to albumin. Serum ...
One of vitamin D’s major functions is to regulate and optimize intestinal calcium absorption for the bone mineral matrix. Try these tasty peach, mango, and apricot gummies to support your bone and joint health. info: We aim to show you accurate product information.Manufacturers, suppliers and ...
Vitamin C has a significant role in modulating neurotransmitter synthesis and release in the brain. The functions of vitamin C in the brain include acting as a co-factor for dopamine beta-hydroxylase in the conversion of dopamine to noradrenaline, involvement in the modulation of both dopaminergic ...
The sun is the major natural source, through eliciting vitamin D production in the skin, but vitamin D is also found naturally in oily fish and eggs and is often added to milk and milk alternatives. Is there a difference between Vitamin D2 and Vitamin D3? There are two forms of Vitamin...
Vitamin C (L-ascorbic acid) is an essential nutrient for human health, and its deficiency has long been known to cause scurvy. Sodium-dependent vitamin C transporters (SVCTs) are responsible for vitamin C uptake and tissue distribution in mammals. Here,
Among the SAM-dependent cellular processes, histone methylation is one of the highest consumers of SAM42,43. Histone modifications play a major role in determining cellular identity changes during reprogramming44,45, and SAM levels are critical for both mouse12and human34embryonic stem cell maintenanc...