Background HTLV-1 predominantly transforms CD4+T cells in vitro and induces leukemia and neurological disease in vivo, whereas HTLV -2 shows a preference for CD8+T cell transformation in vitro with limited in vivo pathology. To better understand cellular tropism of HTLV-1 and HTLV -2 early ...
Human T-Lymphotrophic Virus type I (HTLV-1) is an oncogenic retrovirus. Infection is associated with a variety of human diseases including HTLV-1 associated myelopathy/tropical spastic paraperesis (HAM/TSP). Large numbers of epidemiological, virological, immunological, and clinical studies on HTLV-...
The infectivity of HTLV-1 is tightly cell-associated, and is mediated through a virological synapse. Cell-free virus is largely non-infectious. HTLV-1 does not use viral capture of a cellular proto-oncogene for oncogenesis. Its viral oncoprotein, Tax, is needed to initiate but not maintain ...
The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc
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TitleHumanT-cellleukemiavirustype1(HTLV1)infectioninmalignantlymphomasinaHTLV1-endemicarea,Kagoshima,Japan:HTLV-1in-situ-hybridization(ISH)a..
Bovine leukemia virus (BLV), an oncogenic member of the Deltaretrovirus genus, is closely related to human T-cell leukemia virus (HTLV-I and II). BLV infects cattle worldwide and causes important economic losses. In this review, we provide a summary of a
Human T-cell leukemia virus type 1 (HTLV-1) integrates its proviruses into random sites in host chromosomal DNA. Random integration of the proviruses was o... Y Furukawa,J Fujisawa,M Osame,... - 《Blood》 被引量: 137发表: 1992年 Production of Functionally Deficient Dendritic Cells from...
The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic...
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), a rapidly progressing clonal malignancy of CD4+ T lymphocytes. Exploring the host-HTLV-1 interactions and the molecular mechanisms underlying