The term “protein corona” refers to the layer of proteins that adhere to the surfaces of nanostructures when they encounter biological fluids. Nanoparticles adsorb biomolecules in biological fluids due to the high free energy of their surfaces1. The importance of the corona layer stems from the ...
Given the lack of adaptive signals in the entry proteins, we further hypothesized that within each gene, adaptative changes are likely to be localized to regions of functional importance and/or that are under relatively stronger selective pressures exerted by host immunity. To test this, we focuse...
VIRAL envelope proteinsNeurofibromatosis type 1 (NF1) is an autosomal dominant disease that affects the development and growth of various tissues. NF1 is a major risk factor for the development of malignancies, particularly malignant peripheral nerve sheath tumors, optic gliomas, and leukemia. NF1 ...
The virus belongs to the family Paramyxoviridae and holds single stranded negative sense RNA, encodes 6 structural proteins, and 2 non-structural proteins. Measles occurs only in humans and is transmitted by respiratory droplets, saliva, skin to skin contact, and touching contaminated surface. ...
Since we want to minimize the risk of chimeric proteins that would lead to falsely connected nucleotide sequences, we chose strict default filter criteria of E-value <10−5, amino acid identity >97%, and a nucleotide identity of >99%. We select the best upstream extensions and the best ...
Most of the Ebola virus VP proteins are capable of eliciting protective immune responses and therefore are important to consider as potential components of a vaccine to protect humans from Ebola hemorrhagic fever. An “Ebola ∆VP30” strain replication incompetent virus as been generated with a lac...
IntroductionRespiratory syncytial virus (RSV) infection causes respiratory disease throughout life, with infants and the elderly at risk of severe disease and death. RSV001 is a phase 1 (first-in-man), open-label, dose-escalation, clinical trial of novel genetic viral-vectored vaccine candidates ...
HIV-1 can lead to an inflammatory response produced by the secretion of viral proteins (viral surface glycoprotein 120 (gp120), transactivator of transcription (Tat), and viral protein R (Vpr)), several soluble molecules and cellular products (such as quinolinic and arachidonate acids, adenosine...
Viral proteins implicated in the oncogenic mechanism are noted. 5. Chronic Inflammation A crucial mechanism by which chronic HCV and HBV drive the development of HCC involves chronic liver inflammation. HCV-related HCC often develops exclusively in the context of liver cirrhosis [17]. Although ...
The advantage of using whole-virus vaccines is the breadth of antigenic targets, as this type of platform can deliver all the proteins in the capsid and possibly internal proteins (which are often highly conserved). Licensed vaccines against influenza virus include live attenuated influenza vaccines ...