4. Menko Fred H,Maher Eamonn R,Schmidt Laura S et al. Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment.[J] .Fam Cancer, 2014, 13: 637-44. 5. 佚名. 结节性硬化症相关肾血管平滑...
原文出处:FDA Grants Breakthrough Therapy Designation to Merck’s Novel HIF-2α Inhibitor MK-6482 for Treatment of Certain Patients With Von Hippel-Lindau Disease- Associated Renal Cell Carcinoma 注:以上资讯来源于网络,由香港济民药业整理编辑(如有错漏,请帮忙指正),只为提供全球最新上市药品的资讯,帮助...
Indeed, clear cell renal carcinomas are exquisitely sensitive to VEGF deprivation and four VEGF inhibitors have now been approved for the treatment of this disease.ChuanShenWilliamG.KaelinJr.SDOSSeminars in Cancer BiologyShen C,Kealin W G Jr.The VHL/HIF axis in clear cell renal carcinoma[J]....
and may further provide a predictive trail of treatmentas compared to nonsense and frameshfft mula—tions.【Key words】Von Hippel.Linda;Hypoxia-inducible factor;Renal cell carcinoma;VHL missense muta—tions肾细胞癌(renal cell carcinomas,RCC)是源自肾小管上皮细胞的异质性肿瘤,占肾脏恶性肿瘤的90%,是...
global clinical development head and senior vice-president Dr Marjorie Green stated: “This approval of WELIREG brings the first and only systemic therapy to adult patients in China with certain VHL disease-associated tumours who, to date, have not had access to a non-surgical treatment option ...
In a renal cell culture line, treatment with 5-aza-2'-deoxycytidine resulted in reexpression of the VHL gene. These findings suggest that aberrant methylation of CpG islands may participate in the tumor-suppressor gene inactivations which initiate or cause progression of common human cancers. 展开...
Renal cell carcinoma (RCC) is the most common type of kidney cancer, accounting for 2–3% of all adult tumours1,2. To date, surgery is the main treatment for this kind of cancer, while RCC is notoriously resistant to conventional chemotherapy, possibly through high expression of some multidru...
过Long termnaturalhistoryofhemangiobla磲stomasinpatientswi蝓thvonHippel Lindau扦disease:implicatio鞑nsfortreatment[J].璜JNeurosurg,XX,105(鲚2):248-255.[10]Gr迪anataA,SessaA,Righ铤ettiM,etal.Juvenil erenalcellcarcinom犄aasfirstmanifestat迷ionofvonHippel Lin daudisease[J].JNep溱hrol,XX,17(2):...
www.nature.com/scientificreports OPEN Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down- received: 06 April 2016 accepted: 10 August 2016 Published: 01 September 2016 regulation of HIF-2α and inhibits tumor growth Lixia Chen1,2, Guiyang Xia2, ...
Google Share on Facebook VHL AcronymDefinition VHLVon Hippel-Lindau(disease) VHLVery High Level Language VHLVirtual Health Library(online information resource; Latin-American and Caribbean Center on Health Sciences Information) VHLvon Hippel-Lindau gene ...