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VHL-regulated miRNA profiling We performed small RNA sequencing in the VHL-deficient ccRCC cell line, RCC4, and its isogenic counterparts expressing a functioning VHL protein, RCC4 VHL. Of the 352 miRNAs quantified, 75 were differentially expressed (DE), including 47 upregulated and 28 downregulat...
28., 51. Recognizing that this primary type PPI could be suitably targeted by small-molecule disruptors, in pioneering work, our laboratory in collaboration with the Crews laboratory developed a first-generation of VHL ligands with single-digit micromolar binding affinities based around the central ...
(22) suggests that Ser65 provides van der Waals contacts that contribute to the proper orientation of pVHL His115, a residue playing a central role in interacting with hydroxyproline (see below). In addition, the His115-containing, water-mediated hydrogen-bonding network involves the side chain...
(column normalization) so that the sum of the signal for all protein in each channel was equal to account for sample loading. Mass spectrometry-based proteomics raw data files have been deposited to the ProteomeXchange Consortium via the PRIDE45,46partner repository (PXD018937). Gene Set ...
Background: von Hippel-Lindau disease (VHL) is a heritable multisystem cancer syndrome caused by a germline mutation of the VHL gene.von HippelLindau disease is associated with benign and malignant tumors of the viscera and central nervous system.Missense mutations of the VHL gene account for the...
deciphered the metabolic atlas of ccRCC by using metabolomics profiling, and characterized broad shifts in the central carbon metabolism, the one-carbon metabolism, and the antioxidant response in ccRCC patients [35]. Therefore, how these altered metabolic pathways are wired to regulate cellular ...
Is scientific progress slowing down? I recently got a chance to attend a conference on this topic, centered around a paper byBloom, Jones, Reenen & Webb (2018). BJRW identify areas where technological progress is easy to measure – for example, the number of transistors on a chip. They ...
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Patients are predisposed to a variety of tumours including clear cell renal cell carcinomas (CCRCCs), pheochromocytomas, hemangioblastomas of the retina and central nervous system and benign cysts affecting a variety of organs (Kondo and Kaelin, 2001). Notably, biallelic VHL inactivation also ...