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neoplastic disease that affects approximately 1/36000–45,500 live births [1,2]. VHL disease encompasses various types of tumors, including retinal or central nervous system hemangioblastoma (RH or CNSH), clear cell renal cell carcinoma (RCC), pheochromocytoma (PHE), multiple pancreatic cysts or...
(2019.01.5)39,40,41, search results were filtered using the LDA function MASS Package in R, and data were processed using an in-house informatics pipeline42,43,44. Custom code was not developed in this study. Briefly, peptide spectral libraries were first filtered to a peptide false ...
Structure-guided design of Homo-PROTACs to induce VHL dimerization.aCrystal structures of VHL in complex with VH298 (PDB code 5LLI)19. VHL is shown as a pink surface and the bound ligand as sticks representation with purple carbons, nitrogen atoms in blue, oxygen in red and sulphur in dark...
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