全视网膜激光光凝(panretinal photocoagulation,PRP)一直是糖尿病黄斑水肿(diabetic macular edema,DME)和增生性糖尿病性视网膜病变(proliferative diabetic retinopathy,PDR)等视网膜血管性疾病的治疗金标准,但其具有破坏性,可能会对视网膜神经纤维造成永久性损伤近年...
Significant progress has been made in the development of targeted therapy in metastatic clear cell renal cancer (RCC). However we appear to have reached a plateau in terms of survival with the drugs that are currently available. This is most likely due to cross resistance between drugs. ...
进一步的信息可在The Molecular Basis of Cancer (癌的分子基础), Mendelsohn和Israel编辑,第1章,Murakami等人题名为"Cell cycle regulation, oncogenes, and antineoplastic drugs (纟田胞周期调节、致癌基 因和抗肿瘤药物)",(WB Saunders: Philadelphia, 1995),具体地可在第 13页中找到。 术语"细胞因子"是用于...
VEGF-targeted therapy has been shown to be efficacious as a single agent in renal cell carcinoma and hepatocellular carcinoma, whereas it is only of benefit when combined with chemotherapy for patients with metastatic colorectal, non-small-cell lung and metastatic breast cancer. ...
targeted therapy into current treatment regimens and other studies are exploring whether different strategies for inhibiting these targets will offer greater benefit. It is clear that optimal use of targeted therapy will depend on understanding how these drugs work mechanistically, and recognising that ...
fectivenessofvascularendothelialgrowthfactorfVEGF)pathway—targetedtherapyformRCCbycom— paringitseriectivenesswiththatofimmunotherapy.Theelectronicdatabasesweresearched.Random— izedcontrolledtrials(RCTs)oncomparisonofVEGFinhibitingdrugs(sorafenib,sunitinibandbevaci· ...
Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as VEGF, for the treatment of cancers caused by VHL inactivation, such as clear-cell renal cell carcinoma (ccRCC)...
The phage display method used in this study can be applied to other target molecules, which can lead to the discovery of new drugs and therapies. Moreover, the technology can be used to develop targeted drug delivery systems, which can reduce the side effects of conventional chemotherapy. In ...
Consequently, VEGF and its receptor represent suitable predominant targets for anti-angiogenic drugs. Anti-VEGF therapies are considered alternatives or adjuncts to conventional chemo or radiation therapy. VEGF inhibitors are employed in various cancer therapies, including non-small cell lung carcinoma (...
For targeted therapy however a single molecule has to be identi?ed. Circulating VEGF is one such promising marker.10 VEGF neutralizing antibodies have been reported to enhance the effect of chemotherapy and radiotherapy used for treatment of cancers.10 Among the family of VEGFs, including VEGF-A...