Other drugs that indirectly affect VEGF pathway, such as statins or arsenic trioxide, also have been shown to possess antiangiogenic activity in leukemias. The benefits of these VEGF targeted agents and their current stage of development as novel anti-antiangiogenic therapies in AML are discussed ...
VEGF-targeted therapy has been shown to be efficacious as a single agent in renal cell carcinoma and hepatocellular carcinoma, whereas it is only of benefit when combined with chemotherapy for patients with metastatic colorectal, non-small-cell lung and metastatic breast cancer. ...
The use of vascular endothelial growth factor (VEGF)-targeted agents for treating cancer has increased dramatically over recent decades. These drugs provide considerable benefits in terms of progression-free (PFS) or overall (OS) survival for cancer patients. Of particular importance to clinicians trea...
whereas VEGF is a target that acts in the tumour microenvironment. Clinical studies are focusing on how to best incorporate targeted therapy into current treatment
fectivenessofvascularendothelialgrowthfactorfVEGF)pathway—targetedtherapyformRCCbycom— paringitseriectivenesswiththatofimmunotherapy.Theelectronicdatabasesweresearched.Random— izedcontrolledtrials(RCTs)oncomparisonofVEGFinhibitingdrugs(sorafenib,sunitinibandbevaci· ...
With the indepth studies of molecular mechanisms of renal cell carcinoma (RCC), people have made great progress in the targeted therapy drugs which targete... 吴小荣,刘东明 - 《国际肿瘤学杂志》 被引量: 0发表: 2012年 抗血管内皮生长因子及其受体靶向药物的肾脏毒性 抗血管内皮生长因子(VEGF)及其受...
(RTK) inhibitors that preferentially target VEGF receptor-2 (VEGFR-2/ flk-1/KDR) with high affinity. Unfortunately, however, the striking benefits of anti-VEGF/VEGFR therapy observed in treating mouse tumors have not been translated to the clinic. All of these drugs have had only modest ...
进一步的信息可在The Molecular Basis of Cancer (癌的分子基础), Mendelsohn和Israel编辑,第1章,Murakami等人题名为"Cell cycle regulation, oncogenes, and antineoplastic drugs (纟田胞周期调节、致癌基 因和抗肿瘤药物)",(WB Saunders: Philadelphia, 1995),具体地可在第 13页中找到。 术语"细胞因子"是用于...
Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as VEGF, for the treatment of cancers caused by VHL inactivation, such as clear-cell renal cell carcinoma (ccRCC)...
Hangzhou 310013, Zhejiang, CHINA; 2.Dr.kang International Medical Center,Hangzhou 311215, Zhejiang, CHINA【Abstract】 Vascular endothelial growth factor (VEGF)-targeted anti-cancer drugs are currently most used in thetargeted anti-cancer therapy, and widely used in tumors such as kidney cancer and ...