Currently, biological drug therapy for ocular angiogenesis treatment is based on the administration of anti￢EGF agents via intravitreal route. The molecules approved with this purpose for ocular use include pegaptanib, ranibizumab, and aflibercept, whereas bevacizumab is commonly off﹍abel used in the ...
“Bioavailability” refers to the amount of active drug that reaches its target following administration. Bioavailability is function of several of the previously described properties, including stability, solubility, immunogenicity and pharmacokinetics, and can be assessed using methods known to one skilled...
As a part of our efforts to identify additional ALK inhibitors that may help overcome drug-resistant G1202R mutant (Hatcher et al., 2015), we generated a focused library based on the Alectinib scaffold. We took advantage of the new library to quickly probe the SAR of potential compounds aga...
Treatment drug and haemorrhage in this instance was noted as being “Low.” When comparing the rank of variables between the full list of variables available and those of our model, we noticed for the most part the rank/order of the variables were similar. Minor differences were evident. ...
Natural naphthoquinones and their derivatives exhibit a broad spectrum of pharmacological activities and have thus attracted much attention in modern drug discovery. However, it remains unclear whether naphthoquinones are potential drug candidates for anti-angiogenic agents. The aim of this study was to ...