VEGF receptor signal transduction. Methods Enzymol. 2008;443:261–84.Li X, Claesson-Welsh L, Shibuya M. VEGF receptor signal transduction. Methods Enzymol. 2008; 443 :261–284. doi: 10.1016/S0076-6879(08)02013-2. S0076-6879(08)02013-2 [pii] [ Cross Ref ]Chapter 13 VEGF Receptor ...
angiogenesisthroughdistinctsignaltransductionpathwaysregulatingproliferationandmigrationofendothelialcells.VEGFR3,areceptor forthelymphaticgrowthfactorsVEGF-CandVEGF-D,butnotforVEGF-A,regulatesvascularandlymphaticendothelialcellfunction duringembryogenesis.Loss-of-functionvariantsofVEGFR3havebeenidentifiedinlymphedema.Formation...
FGF2/FGFR1在许多肿瘤中高表达,是肿瘤逃逸抗VEGF治疗的机制之一。 2023年8月18日,中山大学中山眼科中心李旭日及瑞典卡罗林斯卡研究院曹义海教授团队在Signal Transduction and Targeted Therapy杂志发表文章,揭示了VEGF-B令人意想不到的限制血管生成的功能,并阐明了其分子机制,为上述现象提供了至少一种可能的解释。本研究...
playingaroleinseveralhumandiseasessuchasrheumatoidarthritisandcancer.ThesolubleVEGFR1isoverexpressedinplacentainpreeclampsiapatients.VEGFR2hascriticalfunctionsinphysiologicalandpathologicalangiogenesisthroughdistinctsignaltransductionpathwaysregulatingproliferationandmigrationofendothelialcells.VEGFR3,areceptorforthelymphaticgrowth...
VEGF receptor signal transduction. Sci. STKE 2001, RE21 (2001). CAS PubMed Google Scholar Shibuya, M. Structure and dual function of vascular endothelial growth factor receptor-1 (Flt-1). Int. J. Biochem. Cell Biol. 33, 409?420 (2001). Article CAS PubMed Google Scholar Ito, N.,...
2023年8月18日,中山大学中山眼科中心李旭日及瑞典卡罗林斯卡研究院曹义海教授团队在Signal Transduction and Targeted Therapy杂志发表文章,揭示了VEGF-B令人意想不到的限制血管生成的功能,并阐明了其分子机制,为上述现象提供了至少一种可能的解释。本研究显示,VEGF-B结合FGFR1,诱导FGFR1/VEGFR1复合物的形成,从而抑制FGF2...
2023年8月18日,中山大学中山眼科中心李旭日及瑞典卡罗林斯卡研究院曹义海教授团队在Signal Transduction and Targeted Therapy杂志发表了题为“VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway”的文章,揭示了VEGF-B令人意想不到的限制血管生成的功能,并阐明了其分子机制,为上述现象提供了至少一种...
Browse more pathway posters here References VEGF receptor signal transduction. Vascular endothelial growth factor (VEGF) inhibition--a critical review. Ten years of anti-vascular endothelial growth factor therapy. Vascular endothelial growth factor in heart failure.Proteintech...
Matsumoto, Claesson-Welsh: "VEGF receptor signal transduction." in: Science's STKE : signal transduction knowledge environment, Vol. 2001, Issue 112, pp. re21, (2002) (PubMed). Harmer, DeFranco: "Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in...
非专利文献2:Matsumoto et al.,VEGF Receptor Signal Transduction.Sci.STKE.2001.re21 非专利文献3:US Ophthalimic Rev.,2013.6:58-63 技术实现要素: 发明要解决的问题 本发明是鉴于这种状况而作出的,其所要解决的技术问题在于,提供一种新抗体,其以高于现有技术的亲和性与血管内皮生长因子(VEGF)结合,抑制VEGF与...