8.3.3.2VEGF Pathway As mentioned above, VEGFA is highly upregulated in the glioma subset with elevatedMDA-9expression. TheVEGF signalingpathway(KEGG) gene set is indeed enriched amongMDA-9-high gliomas, according to results from the GSEA analysis (ES=0.65) (Fig. 17D). Aside from VEGFA, ...
Among them, 1,189 orthologous genes were differentially expressed, which were enriched in 14 KEGG pathways. More specially, the expressions of hemoglobin genes and various HIF/VEGF signaling pathway genes were obviously upregulated in the ABO of M. anguillicaudatus . Moreover, we found that HIF-...
2.蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络:将交叉靶点信息导入String数据库,以置信水平>0.4为筛选条件下载交叉靶点的PPI信息,并使用Cytoscape软件进行可视化。 3.基因本体(gene ontology,GO)功能与京都基因与基因组...
3c). Kyoto Encyclopedia of genes and genomes (KEGG) is a comprehensive database that combines information on genomic, chemical, and system functions. KEGG analysis showed that the differentially significantly enriched pathways included tryptophan metabolism, Wnt signaling pathway, and VEGF signaling ...
Utilizing pathway annotations from Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Reactome databases within MSigDB [20,21,22,23], we systematically assessed the activation states of diverse signaling pathways. By analyzing the associations between VirHF susceptibility and ...
The KEGG pathway analysis results indicated that ribosome and ribosome-related pathways were highly associated with ovarian development at stage II across both transcriptomes, likely to support the subsequent vitellogenesis by providing the necessary materials. Additionally, the neurodegeneration, MAPK, cAMP ...
(B) KEGG pathway enrichment analysis showing genes involved in PI3K/AKT signaling pathway and cytokine–cytokine receptor interaction were the largest in DXM + GM enema treatment mice compared with ARP mice. Full size image DXM + GM enema ameliorates inflammation by inhibiting NF-κB ...
目的探究miR-424介导的血管内皮生长因子(VEGF)A低表达对宫颈鳞状细胞癌的侵袭和转移的影响.方法建立宫颈癌裸鼠抑制瘤模型,30 d后检测肿瘤体积,肿瘤重量;qPCR检测miR-424表达水平;免疫组化检测Ki67,VEGFA阳性表达率;荧光素酶报告实验验证miR-424-5p与VEGFA靶向关系;将VEGFA构建到腺病毒LV中过表达,SiHa细胞用miR-424...
(VEGFR-1, VEGFR-2, and VEGFR-3)6. VEGF is a signaling glycoprotein identified as a crucial stimulator of angiogenesis by which colon tumors’ growth is promoted via increased nutrient provision7. Moreover, the VEGF-induced signaling pathway is fundamental for tumor progression and participates ...
Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis further revealed that the DEGs were implicated in the regulation of neuroactive ligand–receptor interaction; NF-kappa B, TNF, PI3K-Akt, and VEGF signaling pathways; and axon guidance (Fig. 4E). Taken together, the enriched gene sets all...