Vascular Endothelial Growth Factor (VEGF) Inhibitor Cardiotoxicity: What Should We Know?VEGFCardiotoxicityCardio-oncologyHypertensionHeart failureEchocardiographyPurpose of review Cancer therapy-induced cardiovascular toxicity is a growing clinical problem with many unanswered questions about the optimal screening, ...
VEGF inhibitors are cancer-fighting agents that work by inhibitingangiogenesisthrough the inhibition of the VEGF pathway. Angiogenesis is a process of formation of new blood vessels which involves migration, growth, and differentiation of endothelial cells, which lines the inside wall of blood vessels....
The interfering strategies targeting VEGF/VEGFR2 axis alleviate CNV, such as intravitreal injection of Apatinib (an inhibitor of VEGFR2; in mice)30 BC001 (An antibody of VEGFR2; in rhesus monkeys)31, and heparin (inhibits VEGFR2; in mice)32 further indicate VEGF/VEGFR2 axis can be a potential...
Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control. J. Clin. Invest. 130, 2237–2251 (2020). Article CAS PubMed PubMed Central Google Scholar Strowd, R. E. et al. Safety and activity of a first-in-class oral HIF2-α inhibitor, PT2385, in ...
it was suggested that these changes were side effects of cardiac and/or pulmonary hypoplasia. A small molecule inhibitor of the VEGF receptor Flt-1/KDR, SU5416 (semaxanib; Pharmacia), was reported to increase hematocrit in several patients participating in a clinical trial, but this was attribut...
VEGF-D-induced signaling and biological effects were blocked by the KDR inhibitor SU5614. The finding that differential KDR activation by VEGF-A and VEGF-D has distinct consequences for endothelial signaling and function has important implications for understanding how multiple ligands for the same ...
Because inhibition of VEGFR2 by the multi tyrosine-kinase inhibitor tivozanib at 10 nM and the VEGFR2-specific inhibitor ZM323881 at 500 nM completely prevented VEGF-A165-induced barrier disturbance, we assumed a similar impact of nintedanib (Deissler et al., 2017). Disturbing effects on the ba...
such as the angiotensin inhibitor losartan, which reduces tumor fibrosis by suppressing TGF-β13. The TGF-β inhibitor, galunisertib, improves overall survival in patients with unresectable pancreatic cancer when administered together with gemcitabine16. Another phase I trial of galunisertib in combin...
Among these 15 upregulated genes, Ttc7, Phlpp2 (PH domain and leucine-rich repeat protein phosphatase 2), Ikbkg (inhibitor of kappaB kinase gamma, formerly known as NF-kB essential modulator, NEMO), Gsdmc and Sumo3 (small ubiquitin-like modifier 3) were significantly upregulated after ...
This study indicates that CS5931 has the potential to be developed as a novel therapeutic agent as an inhibitor of angiogenesis for the treatment of cancer. Keywords: CS5931; anti-angiogenesis; zebrafish; HUVECs; VEGF and MMPs 1. Introduction Angiogenesis, the sprouting or intussusception of pre...