Ostendorf T,De Vriese A S,Floege J.Renal side effects of anti-VEGF therapy in man:a new test system.Nephrology Dialysis Transplantation. 2007Ostendorf Tammo,De Vriese An S,Floege Jürgen.Renal side effects of anti-VEGF therapy in man: a new test system.Nephrology, dialysis, transplantation ...
should be considered. “I am hoping that revealing the possible negative side effects of VEGF inhibition in the eye will motivate research into new ways to block edema and blood vessel growth in the eye that does not require continuous inhibition of intraocular VEGF,” said D’A...
Anti-VEGF therapy has provided a ray of hope to diabetic patients who are likely to develop complications like retinopathy and blindness. Here is a brief discussion of what exactly an anti-VEGF therapy means, how it works, possible side effects, and the role it can play in the management of...
"Mice eyes differ from human eyes in many ways, so we cannot directly extrapolate these results to humans, but this study is an important heads-up that clinical application of anti-VEGF therapy in the eye needs to proceed with caution," she adds. From a clinical...
Ocular Anti-VEGF Therapy for Diabetic Retinopathy: The Role of VEGF in the Pathogenesis of Diabetic Retinopathy the pathogenesis of diabetic retinopathy, the molecular characteristics of anti-VEGF agents currently used, and future perspectives and challenges in this area... R Simo,JM Sundstrom,DA Ant...
Current treatment options include steroids which have undesirable side effects, or anti-VEGF which has only limited efficacy. In an inflammatory environment, however, angiogenesis can be stimulated by numerous factors not directly targeted by anti-VEGF therapy. The aim of this study was to induce ...
The following key phrases were used: anti-VEGF agents, corneal neovascularization, bevacizumab, ranibizumab, vascular endothelial grow factor, angiogenesis. Results The use of anti-VEGF therapy in the treatment of CN reduced pathological vessels density without causing significant side effects. Various ...
Anti-VEGF agents are the therapy of choice for wet AMD, yet this treatment can be costly, require strict follow-up and cause psychological and physical side effects, not to mention the heightened risk of geographic atrophy (GA). A recent study published inRetinasuggests that at least some wet...
Anti-VEGF therapy leads to various glomerular injuries, including MCN/FSG- and TMA-like syndromes. In our group of patients, we show for the first time that MCN/FSG lesions, which are mostly observed following RTKI therapy, are associated with a high abundance of c-mip. In contrast, in ...
Biologics targeting vascular endothelial growth factor (VEGF) are the major approach for treatment. However, up to 30% of patients are non-responsive to these drugs and they are associated with ocular and systemic side effects. Therefore, there is a need for small molecule ocular angiogenesis ...