目的分析1,4,5三磷酸肌醇受体(IP 3R)-葡萄糖调节蛋白75(Grp75)-电压依赖性阴离子通道1(VDAC1)-线粒体钙单向转运体(MCU)钙轴分子在肾病蛋白尿时表达变化,探讨其上游调控路径。 方法将SD大鼠分为对照组(6只)和阿霉素(ADR)组(10只)。通过尾静脉1次注射ADR法建立肾病模型。采用免疫组织化学染色分析肾小球钙...
In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) calcium regulation axis, which is located at sites of endoplasmic reticulum (ER) mitochondria coupling, ...
D, E Activation of S1R inhibited PERK and IP3R-VDAC1-MCU signaling pathways and alleviated endoplasmic reticulum stress and mitochondrial damage (n = 3). *:p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001 Full size image S1R attenuates endoplasmic reticulum ...
The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) cal
Symbol Diagram 概述 VDAC8 元件是 一个8 位电压输出数模转换器 (DAC)。输出范围可以从 0 到 1.020...
结论:IP 3R-Grp75-VDAC1-MCU钙轴分子高表达伴mTORC1过度活化参与ADR大鼠肾病模型蛋白尿发生,mTORC1抑制剂显著抑制足细胞钙轴分子表达,可能参与mTORC1抑制剂所致足细胞效应机制.doi:10.3760/cma.j.cn101070-20200613-00987王斯斯北京大学第一医院管娜北京大学第一医院许晗北京大学第一医院魏骐骄北京大学第一医院陶...
目的:分析1,4,5三磷酸肌醇受体(IP\n3R)-葡萄糖调节蛋白75(Grp75)-电压依赖性阴离子通道1(VDAC1)-线粒体钙单向转运体(MCU)钙轴分子在肾病蛋白尿时表达变化,探讨其上游调控路径.\n方法:将SD大鼠分为对照组(6只)和阿霉素(ADR)组(10只).通过尾静脉1次注射ADR法建立肾病模型.采用免疫组织化学染色分析肾小球...
PFOS induces lysosomes-regulated mitochondrial fission in hepatocytesin vivoandin vitro.PFOS induces autophagy-dependent MCU oligomerization that mediates mitochondrial fission.TRPML1/VDAC1/MCU per se, rather than the calcium transfer, regulates mitochondrial fission.MCU mediates the increase in ATP5J2 ...