目的分析1,4,5三磷酸肌醇受体(IP 3R)-葡萄糖调节蛋白75(Grp75)-电压依赖性阴离子通道1(VDAC1)-线粒体钙单向转运体(MCU)钙轴分子在肾病蛋白尿时表达变化,探讨其上游调控路径。 方法将SD大鼠分为对照组(6只)和阿霉素(ADR)组(10只)。通过尾静脉1次注射ADR法建立肾病模型。采用免疫组织化学染色分析肾小球钙...
采用Fluo-4对细胞质的钙进行染色，发现与对照组相比，TM组细胞质的钙荧光强度显著增加，但在加入siRNA处理后，TM组的细胞质钙的荧光强度没有显著影响（图3D、E）。且TM处理后，线粒体的钙积累显著高于对照组（图3F、G），同时增加了VDAC1和MCU（线粒体钙离子通道蛋白）在线粒体膜上的表达，GRP75 siRNA处理使...
In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) calcium regulation axis, which is located at sites of endoplasmic reticulum (ER) mitochondria coupling, ...
D, E Activation of S1R inhibited PERK and IP3R-VDAC1-MCU signaling pathways and alleviated endoplasmic reticulum stress and mitochondrial damage (n = 3). *:p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001 Full size image S1R attenuates endoplasmic reticulum ...
In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) calcium regulation axis, which is located at sites of endoplasmic reticulum (ER) mitochondria coupling, ...
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1 2024, Current Cancer Drug Targets VDAC1 Protein Regulation of Oxidative Damage and Mitochondrial Dysfunction-Mediated Cytotoxicity by Silica Nanoparticles ...
IP 3R-Grp75-VDAC1-MCU钙轴分子高表达伴mTORC1过度活化参与阿霉素大鼠肾病模型蛋白尿发生 目的:分析1,4,5三磷酸肌醇受体(IP\n3R)-葡萄糖调节蛋白75(Grp75)-电压依赖性阴离子通道1(VDAC1)-线粒体钙单向转运体(MCU)钙轴分子在肾病蛋白尿时表达变化,探讨其上游... 王斯斯,管娜,许晗,... 被引量: 0发表...
H, Western blot detection of mitochondria calcium protein VDAC1 and MCU levels in atrial myocytes. Quantification of VDAC1 (I) and MCU (J) protein levels in (H). K, Ultrastructural changes in HL-1 cells (green stars depict the mitochondria; white arrowheads depict the ER; red arrowheads ...
Symbol Diagram 概述 VDAC8 元件是 一个8 位电压输出数模转换器 (DAC)。输出范围可以从 0 到 1.020...
PFOS induces endoplasmic reticulum (ER) iron overload.ZIP7 is responsible for ER iron efflux, specifically to mitochondria.VDAC3/MCU of mitochondria is involved in PFOS-induced ER-mitochondria iron transfer.ACSL4 regulates ZIP7-VDAC3 interaction and subsequent ER-mitochondria iron transfer.The ER-mi...