Vasopressin (V) receptors have diverse physiological actions on liver, smooth muscle, myocardium, platelets, brain, and kidney. Although both V1a and V1b receptors stimulate the heterotrimeric G-protein subtype Gq resulting in activation of phospholipase C with increasing inositol phosphate production ...
Vasopressin (AVP) drives urinary concentration via V2 receptors in the distal nephron and collecting duct of the kidney. Parallel activation of V1a receptors (V1aR) has been implicated in renal acid-base handling, but cell type-related information on this receptor is still scarce. We ...
Use of model organisms and in vitro techniques relevant to developmental biology and medicine are acceptable, as are translational human studies.doi:10.1203/00006450-197804001-01105Robillard, Jean EWeitzman, Richard ESmith, Fred GPediatric Research...
(or V1b). V2receptors are present in the renal collecting duct, while V1receptors are located in the vascular bed, kidney, bladder, spleen, and hepatocytes, among other tissues.49AVP is released in response to small increases in plasma osmolality or large decreases in blood pressure or ...
Increased cell proliferation and fluid secretion, probably driven by alterations in intracellular calcium homeostasis and cyclic adenosine 3,5-phosphate, play an important role in the development and progression of polycystic kidney disease. Hormone receptors that affect cyclic adenosine monophosphate and ...
Vasopressin (AVP) plays a major role in the regulation of water and sodium homeostasis by its antidiuretic action on the kidney, mediated by V2 receptors. AVP secretion is stimulated by a rise in plasma osmolality, a decline in blood volume or stress. V1a receptors are expressed in vascular ...
The hepatic, vascular-type (V1aR) and the renal, antidiuretic-type (V2R) vasopressin receptor cDNAs were recently cloned from rat liver and kidney libraries, respectively. DNA fragments containing the region encoding the putative 5/6 transmembrane loops of these receptors were subcloned, separately...
vasopressin- hormone secreted by the posterior pituitary gland (trade name Pitressin) and also by nerve endings in the hypothalamus; affects blood pressure by stimulating capillary muscles and reduces urine flow by affecting reabsorption of water by kidney tubules ...
5. Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells: M. Greenwood, et al.; Mol. Metab. 63, 101542 (2022) 6. Activation of Orexin 1 Receptors in the Paraventricular Nucleus Contributes to the Development of Deoxycorticosterone Acetate-Salt Hypertension Through Regulation of ...
they can be distinguished on the following grounds—(1) renal vasopressin receptors are coupled to adenylate cyclase, (2) kidney and liver vasopressin receptors are affected by triphosphonucleotides, and (3) hepatic and aortic vasopressin receptors in the rat have almost identical recognition patterns...