Preformed aquaporin-2 also migrates and inserts into the luminal membrane of the tubule cells, where it acts a conduit for water to be reabsorbed from the urine, through the cell, and back into the circulation. This leads to a decrease in renal free water clearance, concentration of urine,...
Vasopressin (AVP) induces antidiuresis by inserting aquaporin-2 (AQP2) water channels in the apical plasma membrane of renal cells, resulting in water uptake. Most AQP2 gene mutation cause recessive nephrogenic diabetes insipidus (rNDI), a disease in which the antidiuretic response is lacking, ...
Vasopressin is involved in the regulation process of hypothalamic-pituitary-adrenal axis, increasing the amount of solute free water reabsorbed from the renal tubule's colate back into the circulation, narrowing arteries to increase pressure, enhancing the stimulating effect of corticotropin releasing ...
Vasopressin induces the contraction or relaxation of certain types of smooth muscle and, in addition, promotes the movement of water (and in some instances of sodium... A Taylor,R Maffly,L Wilson,... - 《Annals of the New York Academy of Sciences》 被引量: 0发表: 1975年 Physiology of...
control. water channel causes a decrease in intracellular NaCl concentration, which subsequently stimulates NKCC1 expression. These data clearly indicate that NKCC1 participates in acute regulatory volume increase, particularly in the presence of AVP. Renal medullary cells are also known to increase ...
(V1R) is a Gq/11-coupled receptor located in VSM cells, where it promotes vasoconstriction and thus raises blood pressure, whereas V2R is a Gsprotein-coupled receptor, located mainly in the renal tubular epithelial cells of the distal nephron, where it regulates renal water reabsorption.92...
Vasopressin (AVP) increases water permeability in the renal collecting duct through the regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and inappropriate antidiuretic hormone secretion (SIADH), are associated with abnormalities in water homeostasis. It has been shown...
Acute renal failure commonly occurs with severe sepsis and is associated with high mortality. Pharmacologic administration of vasopressin (VP) increases urine output in septic shock. To elucidate the mechanism by which pharmacologic VP induces diuresis, VP was administered at a low dose of 10 and a...
Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel. Proc. Natl Acad. Sci. USA 103,... To regulate mammalian water homeostasis, arginine-vasopressin (AVP) induces phosphorylation and thereby redistribution of renal aquaporin-2 (AQP2) water ch... EJ ...
et al. Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney. PLoS One 6, e24277 (2011). Article CAS ADS PubMed PubMed Central Google Scholar Pao, A. C. SGK regulation of renal sodium transport. Curr Opin Nephrol ...