Background:Many recent studies suggest that vasopressin deficiency is an important cause of catecholamine-resistant hypotension with vasodilation in adults, but little is known about vasopressin deficiency in children. Methods:To clarify the usefulness of vasopressin administration in pediatric cathecolamine-...
Yet comparatively low AVP levels have been reported in patients with septic shock and in hemodynamically unstable organ donors, suggesting that clinical states of “relative vasopressin deficiency” may exist, and that these might respond to exogenous vasopressin administration. AVP has thus been ...
NKCC1 deficiency is reported to be associated with greater blood pressure increase during high salt intake at night and greater blood pressure decrease during low salt intake during the day.37 Although hypereninemic hyperaldosteronism was reported, the precise mechanism of altered salt sensitivity in ...
Vasopressin Deficiency Contributes to the Vasodilation of Septic Shock BACKGROUND: The hypotension of septic shock is due to systemic vasodilation. On the basis of a clinical observation, we investigated the possibility that a... SE Buijk,HA Bruining,JA Oliver,... - 《Circulation》 被引量: 14...
Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med 7: 62 The authors demonstrate that OXTR methylation can lead to expression changes in the temporal cortex in the context of autism. Guastella AJ, Einfeld SL, Gray KM, Rinehart NJ, Tonge BJ, Lambert TJ et al...
Just as central DI is caused by ADH deficiency, syndrome of inappropriate ADH secretion (SIADH) is caused by an excess production of ADH that is inappropriate with respect to the state of the intravascular volume (seeChapter 5, “Regulation of Fluids and Electrolytes”). The most common causes...
Severe hemorrhagic shock, however, is associated with a state of arginine vasopressin (AVP) deficiency, and supplementation of this hormone may decrease the need for blood products in resuscitation. Objective To determine whether low-dose supplementation of AVP in patients with trauma (hereinafter ...
3. The Brattleboro Rat as a Model of AVP-Deficiency The Brattleboro rat strain was discovered in 1961 in Brattleboro, Vermont. It evolved from the Long–Evans rat strain through a random autosomal recessive mutation (Figure 2A). The genetic mutation of the Brattleboro strain was later confirmed...
A few of gain-of-function mutations, such as R137C, R137L I130N and F229V that cause constitutive activation of receptors, leading to X-linked nephrogenic syndrome of inappropriate antidiuresis (NSIAD)15, 16, while most of AVPR2 gene mutations are loss-of-function that cause X-linked ...
Other models of prenatal challenge, such as the prenatal zinc deficiency model, also result in offspring procedural learning deficits50 and striatal enlargement51. Similarly, genetic mouse models of ASD, as well as human ASD, are associated with increased striatal volume relative to total brain ...