Inappropriately, high plasma AVP concentrations ([AVP] p ) associated with low blood sodium concentrations facilitate fluid retention and sodium loss, thereby possibly reconciling both the water intoxication and sodium loss theories of hyponatraemia that are currently under debate. Therefore, given the ...
fluid detectionNineteen patients were studied during the first 4 days after withdrawal from alcohol. Plasma vasopressin was raised ( P < 0.05) and fluid retention occurred ( P < 0.05), with falls in haematocrit ( P < 0.01) and calculated plasma osmolality ( P < 0.02), which were consistent...
V1a activation could cause vasoconstriction and/or direct myocardial hypertrophy as intracellular signaling pathways are closely related to those for angiotensin II. V2 activation could cause fluid retention and hyponatremia. A hemodynamic study with the pure V2 antagonist tolvaptan (TV) showed minimal ...
In addition, adrenocorticotropic hormone (ACTH) and catecholamine release via V1bR and body fluid retention via V2aR contribute to blood pressure regulation. In the pituitary, AVP synergistically controls the secretion of ACTH with corticotropin-releasing hormone (CRH). AVP also regulates metabolic ...
Vasopressin injected into the brain ventricles of the rat and guinea pig shows a rate of clearance from CSF with a terminal half-life of 26 min.21,27 This is in excess of the rate of turnover of CSF in these species produced by the secretion and turnover of fluid and suggests a specif...
Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and disorders of water retention such as congestive heart failure ... LL Wong,JG Verbalis - 《Cardiovascular Research》 被引量: 706发表: 2001年 Exercise-associated hyponatremia: A review This paper reviews the ...
heart failuretolvaptanvasopressin V2 receptor antagonismDespite diuretics being used to relieve the fluid retention/congestion associated with heart failure (HF),... SA Doggrell - 《Expert Opin Pharmacother》 被引量: 70发表: 2004年 Clinical profile and prognostic value of low systolic blood pressure ...
arginine vasopressin oligo, oligohydramnios HZ, heterozygotes HO, homozygotes the organ itself (e.g. secretion/retention of fetal lung fluid) (2, 3) and by extrinsic forces, both phasic and tonic (4, 5), that expand the lung from the outside (fetal breathing and chest wall recoil). Be...
and insertion into the epithelial cell membranes, increasing the efficiency of water retention and aggravating the pathology. However, the induced volume expansion and hypotonicity act on the tubular cells of the collecting duct to decrease the content and action of aquaporin 2, thereby decreasing ...
Because Na+ is one of the major determinants of extracellular fluid osmolarity, changing extracellular Na+ levels may alter both the agonist binding and internalization processes in GPCRs. However, the overall effect of changing the levels of extracellular Na+ ions on the internalization of GPCRs ...