Smooth muscle contraction occurs via a sliding filament mechanism similar to that in striated muscles. The contractile apparatus of smooth muscle consists of the contractile proteins—actin/tropomyosin and myosin that are organized into thin and thick filaments, respectively—and associated regulatory protei...
Mochalov, S.V., Kalenchuk, V.U., Gainullina, D.K., Vorotnikov, A.V., and Tarasova, O.S., The contribution of protein kinase C and rho-kinase to the regulation of receptor-dependent contraction of arteries decreases with age independently of sympathetic innervation,Biophysics(Moscow), ...
Gi-proteins in vascular smooth muscle are coupled to α2-adrenoceptors. Binding of these receptors to an agonist such as norepinephrine reduces cAMP, which leads to smooth muscle contraction. Gq-proteins in vascular smooth muscle are coupled to α1-adrenoceptors (bind to norepinephrine), ETA re...
aThe activation of intracellular signaling cascades by Fc eRI ligation leads to the exocytotic release of granular contents (degranulation), resulting in allergic responses such as an increase in vascular permeability and stimulation of smooth muscle cell contraction . 活化作用 细胞内 信号小瀑布由Fc eRI...
(EPA), an omega-3 polyunsaturated fatty acid (n-3 PUFA), effectively inhibits sphingosylphosphorylcholine (SPC)-induced Ca2+-sensitization of vascular smooth muscle (VSM) contraction which is a major cause of cardiovascular and cerebrovascular vasospasm, and EPA is utilized clinically to prevent ...
larsmoothmusclecellcontractionwasdecreased.【Conclusion】CNPcanactivatecGMP‐PKGIasignalagainst 5‐HT‐inducedaorticvascularsmoothmusclecellcontraction.ItindicatesthatCNPcanbeusedasaneffective targetforthepreventionandtreatmentofatherosclerosis. [Keywords]Aorta;Muscle,Smooth,Vascular;SignalTransduction [中图分类号]R543.1...
We previously reported that eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid (n-3 PUFA), effectively inhibits sphingosylphosphorylcholine (SPC)-induced Ca2+-sensitization of vascular smooth muscle (VSM) contraction which is a major cause of cardiovascular and cerebrovascular vasospasm...
We tested whether the gender differences in vascular smooth muscle (VSM) function reflect differential expression/activity of ERα, ERβ and the newly-identified GPR30. Single aortic VSM cells (VSMCs) were freshly isolated from male and female Sprague-Dawley rats, and their contraction to ...
Thus, a rise in cytosolic Ca2+ concentration produces smooth muscle contraction by activation of MLCK and consequent phosphorylation of MLC. However, it is now well established that MLC phosphorylation and tension can be induced independently of change in cytosolic Ca2+ concentration (1, 2). ...
In vivo effects of angiotensin II on vascular smooth muscle contraction and blood pressure are mediated through a protein tyrosine-kinase-dependent mechanism. 来自 NCBI 喜欢 0 阅读量: 32 作者:MD Sauro,R Sudakow,S Burns 摘要: The effects of in vivo angiotensin II (AII) treatment on protein ...