Smooth muscle contraction occurs via a sliding filament mechanism similar to that in striated muscles. The contractile apparatus of smooth muscle consists of the contractile proteins—actin/tropomyosin and myosin that are organized into thin and thick filaments, respectively—and associated regulatory protei...
Increased vascular resistance during systemic nitric oxide synthase (NOS) inhibition is dependent on adrenergic vasoconstriction. This study tested the hypothesis that increased vascular sensitivity to adrenergic agonists contributes to this vasoconstriction. Superior mesenteric arteries and thoracic aortae from ...
Vascular smooth muscle contraction is triggered by a rise in the intracellular free Ca2+ concentration, the amplitude of the contractile activity being dependent on the magnitude of the calcium signal. The change in the Ca2+ concentration can be due to an increased influx of Ca2+ from the ...
[...]neurohypophysis can stimulate the contraction of uterinesmooth muscleatterm and that of myoepithelial cells that surround [...] actazool.org actazool.org 催产素受体(OTR)是与G-蛋白相耦联的膜蛋白,通过激活磷脂酶C发挥其生理作用。 actazool.org ...
MuscleCellContraction LIYong‐jie,ZENGDing‐yin(ThirdPeople'sHospitalofLiaoyang City,Liaoning111000,China) [Abstract]【Objective】ToexploretheeffectofC‐typenatriureticpeptide(CNP)onantagonizing5‐ hydroxytryptamine(5‐HT)‐inducedaorticsmoothmusclecellcontractionanditsmechanism.【Methods】CNP stimulatedA10aorticsmo...
CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese miceCPI-17Calcium sensitizationObesity-related hypertensionSeveral factors have been implicated in obesity-related hypertension, but the genesis of the hypertension is largely unknown. In this ...
aThe activation of intracellular signaling cascades by Fc eRI ligation leads to the exocytotic release of granular contents (degranulation), resulting in allergic responses such as an increase in vascular permeability and stimulation of smooth muscle cell contraction . 活化作用 细胞内 信号小瀑布由Fc eRI...
(EPA), an omega-3 polyunsaturated fatty acid (n-3 PUFA), effectively inhibits sphingosylphosphorylcholine (SPC)-induced Ca2+-sensitization of vascular smooth muscle (VSM) contraction which is a major cause of cardiovascular and cerebrovascular vasospasm, and EPA is utilized clinically to prevent ...
These findings support the conclusion that aldosterone enhances and prolongs contraction by inhibiting the removal of catecholamines from the receptor compartment of vascular smooth muscle.doi:10.1159/000158457Ralph E. PurdyDepartment of Pharmacology and Hypertension Center-Department of Medicine, University of...
We previously reported that eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid (n-3 PUFA), effectively inhibits sphingosylphosphorylcholine (SPC)-induced Ca2+-sensitization of vascular smooth muscle (VSM) contraction which is a major caus