High resolution peripheral quantitative computed tomography (HRpQCT) is able to assess bone microstructure in renal osteodystrophy and lower leg arterial calcification (LLAC) is usually seen as an incidental finding. LLAC can be a useful quantitative assessment of VC in CKD but the relationship ...
Alizarin Red S staining confirmed that CM successfully induced VSMC calcification (Fig. 1G). Over the course of osteogenic induction, the mRNA and protein levels of BRCC36 were significantly lower in calcified VSMCs than in control VSMCs (cultured in growth medium (GM)) (Fig. 1H, J). ...
The calcifications can be seen on a plain radiograph and are a very useful sign for confirming a diagnosis of venous malformations and ruling out other conditions. When deep, the lesions can affect muscles, joints, and bones, and can even cause bone deformities or pathologic fractures. When ...
Vascular calcification, prevalent in diabetes and chronic kidney disease, contributes to morbidity and mortality. To investigate the effect of receptor activator of NF-kB ligand (RANKL) on vascular calcification in vivo, transgenic mice, where RANKL expression was targeted to vascular smooth muscle cell...
Both inflammatory cytokines and ROS induce the secretion of matrix metalloproteinase and transforming growth factor β1 that mediate ECM remodeling including elastin fragmentation, collagen accumulation and calcification17. Increased NF-κB activity upregulates the expression of endothelial adhesion molecules to...
2) Do not use in patients with severe calcification of the access vessel and/or common femoral artery stenosis resulting in a vessel <5mm in diameter for the 14F MANTA or <6mm in diameter for the 18F MANTA, or>50% diameter femoral or iliac artery stenosis. 3) Do not use in patients ...
Decisions regarding the treatment of peripheral arterial disease of the lower limb, while based on the clinical features, may be clarified by non-invasive investigations. Absent pulse(s) in the leg, alone, are enough to determine the presence of arterial disease, and non-invasive tests are not...
The adult-onset condition is associated with progressive and painful arterial calcification affecting the lower extremities, yet spares patients' coronary arteries. The new disease finding was published today in the New England Journal of Medicine. The rare arterial condition caused by calcium buildup ...
[3,4]. The ABI is a very useful clinical index for assessing arterial blood supply to the foot, but there are limitations when used in consideration of people with diabetes [4]. Medial calcification in diabetes, known as Mönckeberg’s sclerosis, causes the incompressibility of the foot ...
Relaxation ofvascular smooth muscle(VSM) is a common goal of drug therapies whose ultimate goal is to lower vascular resistance, reduce blood pressure (BP), and increase blood flow. In acutely ill patients in states of shock due to infection or inadequate cardiac output a goal of drug therapie...