从Alpha到Omicron 2020年12月下旬,研究人员发现新冠病毒的一个新谱系正在英国部分地区迅速传播,其在S基因上携带有大量突变。后来,Pango将该谱系归类为B.1.1.7,WHO则命名为VOC Alpha。在接下来数周,南非和巴西又分别报道了另外两个快速...
什么是Naïve B cell 与T细胞类似,B细胞也是从干细胞分化而来,通过接触独特的抗原分化后激活。B细胞表面受体BCR与外来抗原结合后发挥下游生物学功能。通常来说,B细胞发育的最后阶段在脾脏中,在那里发育成初始B细胞。这些不被激活的初始B细胞随着血液进入到刺激淋巴器官(SLO)。初始的B细胞更容易捕获病原体,因为SLO的...
Rodney Rohde, PhD, MS, SM(ASCP)CM, SVCM, MBCM, FACSc:Madeline, in your work, do you talk about the differences between variants of concern and variants of interest, or that type of information around these strains? Madeline King, PharmD, BCIDP:That’s a great question. In the clinical...
The B.1.1.7 lineage (known as 20I/501Y.V1 or variant of concern [VOC] 202012/01) was first detected in the UK in December 2020 with likely emergence during the preceding September; this variant has now been identified in at least 80 countries.1The first identified US case of the B.1...
domain, TM transmembrane region, CT cytoplasmic terminus.dA list of SARS-CoV-2 strains, harboring mutations in the RBD region of S glycoprotein, that could effectively infect wild-type mice.eSchematic demonstration of the mouse as a transmitter of the SARS-CoV-2 N501Y variants of concern. ...
Since the late 2020, the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern has been characterized by the emergence of spike protein mutations, and these variants have become dominant worldwide. The gold standard SARS-CoV-2 diagnosis protocol requires two...
Early detection of the emergence of a new variant of concern (VoC) is essential to develop strategies that contain epidemic outbreaks. For example, knowing in which region a VoC starts spreading enables prompt actions to circumscribe the geographical area where the new variant can spread, by conta...
The increased infectivity and transmissibility of SARS-CoV-2 variants of concern (VOCs) could cause significant human and economic damage. Hence, understanding their characteristics is crucial to control infection. We evaluated the environmental stability of the Wuhan strain and all VOCs (Alpha, Beta,...
Codon usage divergence in Delta variants (B.1.617.2) of SARS-CoV-2 2022, Infection, Genetics and Evolution Citation Excerpt : For rapid characterization of SARS-CoV-2, Centers for Disease Control and Prevention (CDC) has classified these variants of concern (VOC), viewing current variants that...