从Alpha到Omicron 2020年12月下旬,研究人员发现新冠病毒的一个新谱系正在英国部分地区迅速传播,其在S基因上携带有大量突变。后来,Pango将该谱系归类为B.1.1.7,WHO则命名为VOC Alpha。在接下来数周,南非和巴西又分别报道了另外两个快速...
丹尼尔·林伍德团队的研究重点是确定种系B细胞抗原如何靶向识别控制下游抗体反应中的表位,同时他们专注于研究抗体库中基因编码的模式识别基序如何识别HIV和流感病毒上 “难以看到”的疫苗靶点。为了测试这一点,我的实验室部署了人源化小鼠疫苗模型,在该模型中,可以通过实验将抗体V基因输入改变为完全不同的人源化BCR库。
this is why we have to have these bivalent vaccines, because we’ve gone from a variant of interest to a variant of concern. This is a problem we have to deal with. It’s important
among which three variants, B.1.1.7, B1.351, and P.1, displayed increasing transmissibility, and therefore were categorized by the world health organization (WHO) as variants of concern (VOC). By 29 March 2021, these three variants have been constituting about two-thirds of SARS...
Early detection of the emergence of a new variant of concern (VoC) is essential to develop strategies that contain epidemic outbreaks. For example, knowing in which region a VoC starts spreading enables prompt actions to circumscribe the geographical are
The B.1.1.7 lineage (known as 20I/501Y.V1 or variant of concern [VOC] 202012/01) was first detected in the UK in December 2020 with likely emergence during the preceding September; this variant has now been identified in at least 80 countries.1The first identified US case of the B....
Since the late 2020, the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern has been characterized by the emergence of spike protein mutations, and these variants have become dominant worldwide. The gold standard SARS-CoV-2 diagnosis protocol requires two...
The increased infectivity and transmissibility of SARS-CoV-2 variants of concern (VOCs) could cause significant human and economic damage. Hence, understanding their characteristics is crucial to control infection. We evaluated the environmental stability of the Wuhan strain and all VOCs (Alpha, Beta,...
Increased Household Transmission of COVID-19 Cases Associated with SARS-CoV-2 Variant of Concern B. 1.617. 2: a National Case Control Study. Public Health England (2021) chrome-extension http://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=https%3A%2F%2Fkhub.net%2Fdocuments%2F13593956...
(B.1.351, first observed in South Africa), Gamma (P.1, first observed in Brazil), and Epsilon (B.1.427 and B.1.429, first observed in California) have all been identified by the American Centers for Disease Control and Prevention (CDC) as either variants of concern (VoCs) or variants ...