Perioperative Prophylaxis†Cardiac, Neurosurgical, Orthopedic, Thoracic (Noncardiac), or Vascular Surgery† IV A single 15-mg/kg dose given IV.Because vancomycin should be infused over 1–2 hours, start the infusion within 120 minutes prior to the time of incision....
Dual-Agent Antibiotic Prophylaxis Using Single Dose Vancomycin Effectively Reduces Prosthetic Joint Infection Rates with Minimal Renal Toxicity Riskdual-agent antibioticprimary total hip arthroplastyprimary total knee arthroplastyprosthetic joint infection
Prophylaxis of infection in cardiac, thoracic, and arterial procedures; craniotomy; joint replacement; amputation 15 mg/kg IV over 1-2 hours; begin administration within 2 hours before incision; duration of prophylaxis for most procedures should be less than 24 hours Dosing Modifications Renal impairm...