Based on these models, optimal vancomycin dosing recommendations were developed using serum creatinine, cystatin C, or both. Conclusions: The proposed vancomycin dosing model, using eGFR from CKD-EPIcreatinine-cystatin C, is expected to achieve target troughs about 2.5-fold more often than cur...
fail FMT or do not wish to have it can be managed by daily dosing with small amounts of vancomycin which prevent recurrent disease. These patients do not have any symptoms of diarrhea or abdominal pain and can lead a normal life simply by taking a single 125 mg dose of vancomycin every ...
Having shown that NEN does not affect the structure or composition of the microbiota, we next asked whether NEN (alone or combination with vancomycin) was potentially able to help restore the gut microbiota during the resolution phase of infection. To this end, we compared the effects of NEN (...
Seven patients were treated with vancomycin exclusively, and one patient with M+CDI did not receive treatment at the discretion of the treating physician. Treatment courses included 10 days, 14 days, 6 week taper, or prolonged (>4 weeks) dosing. One patient in the IBD group and one in the...
The intent of this study was to evaluate the appropriateness of commonly used intravenous (iv) vancomycin dosing schemes in patients on automated peritoneal dialysis (APD) using population pharmacokinetic (PK) modelling and Monte Carlo simulation.Data from a single-dose PK study of 10 non-infected ...
Is Cystatin C Good Enough as a Biomarker for Vancomycin Dosing: A Pharmacokinetic Perspective.doi:10.1007/s13318-019-00587-3Guo YuGuo-Fu LiEur J Drug Metab Pharmacokinet
The cadazolid geometric mean MIC was 152-fold, 16-fold, 9-fold and 7-fold lower than those of moxifloxacin, linezolid, metronidazole and vancomycin, respectively. Both cadazolid dosing regimens rapidly reduced C. difficile viable counts and cytotoxin with no evidence of recurrence. Cadazolid levels...