Valproic acidReactions Weekly -doi:10.2165/00128415-199605970-00036Springer International PublishingReactions Weekly
Valproic Acid (VPA) is an important drug for the treatment of several types of seizures because it has a wide spectrum of activity. Since VPA has an unusual nonlinear binding characteristic and a wide interindividual variation, monitoring of its free concentration can be helpful in patient manageme...
Related to valproic acid:Divalproex,Sodium valproate val·pro·ic acid (văl-prō′ĭk) n. Ananticonvulsivedrug,C8H15NaO2,givenorallyandbyinjectiontotreatepilepsy. [val(eric acid)+pro(pyl)+-ic.] AmericanHeritage®DictionaryoftheEnglishLanguage,FifthEdition.Copyright©2016byHoughtonMifflinHarcourt...
carbamazepine, phenobarbital, primidone) can decrease plasma concentrations of valproic acid. Adjustment of valproic acid dosage may therefore be necessary when such drugs are initiated or withdrawn. Salicylates increase free and total plasma valproate concentrations by inhibition of valproate metabolism and ...
valproic acid was associated with other antiepileptic drugs (Rasalam et al., 2005). In a large population-based study on Danish people,Christensen et al. (2013)found 508 children exposed in utero to valproic acid and 2136 to other anticonvulsant drugs over a total of 655,615 eligible ...
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Conversion to IV valproate preparations: To continue therapy IV in patients temporarily unable to receive oral therapy, total daily IV dose should be equivalent to the total daily oral dose (expressed as valproic acid) and divided every 6 hours. Trough levels may fall below the equivalent oral ...
The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients. ASD prevalence is higher in boys, but increasing evidence suggests under
The present invention relates to the use of valproic acid and derivatives thereof as an inhibitor of histone deacetylases. The invention also concerns the use of those compounds for the manufacture of a medicament for the treatment of diseases associated with histone hypoacetylation or in which a ...
The clinical role and underlying mechanisms of valproic acid (VPA) on bone homeostasis remain controversial. Herein, we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density (BMD) in both patients and mice. This ef