Valproic acid (VPA) supplementation (100mg/kg) daily for four weeks brought back all the above parameters to near normal level. The above outcomes were confirmed by the histopathological examination. No significant (P<0.05) effect was observed in control rats treated with valproic acid (100mg/...
and also in human children, via a GABAergic mechanism. Recently, our group found that the patients treated with valproic acid showed a significant increase in visual evoked potential P100latencies even after 12 months of therapy, in presence of normal blood levels of this antiepileptic drug[14]....
Objective To investigate the radioprotective effects of valproic acid( VPA),an antiepileptic drug,on the normal brain tissues of rats. Methods A total of 48 male Wistar rats were randomized into VPA group,radiotherapy group...
doi:10.1080/j.1440-1614.2006.01892.xLETTERSPSYCHIATRYA letter is presented in response to an article on polydipsia published in a previous issue of the periodical.Australian & New Zealand Journal of PsychiatryGuaiana, GiuseppeEyrek, CetinMariconda, Giuseppe...
Valproic acid is a carboxylic acid designated as 2–propylpentanoic acid. It is also known as dipropylacetic acid. Valproic acid (pKa 4.8) has a molecular weight of 144 and occurs as a colorless liquid with a characteristic odor. It is slightly soluble in water (1.3 mg/ml) and very solu...
VALPROIC ACID capsules, for oral use Initial U.S. Approval: 1978 WARNING: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepatotoxicity, including fatalities, usually during the first 6 months of treatment. Children under the age of two years and...
Nonetheless, the PLT counts were still within the normal range, and none of the patients had a PLT count < 100 × 109/L. After the long-term VPA monotherapy, the serum calcium level in the ≥ 3 years group was significantly lower than that in the < 1 year group (...
Hypersensitivity to valproic acid, divalproex, derivatives, or any component of the formulation; hepatic disease or significant impairment; urea cycle disorders; prevention of migraine in pregnant women and women of childbearing potential who are not using effective contraception; known mitochondrial ...
During her hospital stay, the woman's ammonia level rose to 211 microg/dL despite a normal valproic acid concentration. She was confused, somnolent, and had decreased mobility. Her platelet count decreased from 133 to 86 x 10(3)/mm(3). Gabapentin was prescribed for seizure control. The ...
Her serum ammonia level was 94 mol/L. Her serum valproate concentration was normal. An EEG revealed marked generalised background slowing consistent with a metabolic encephalopathy. The woman received enteral lactulose in an ICU. Topiramate and valproic acid were discontinued. Within 4 days, she ...