Valproic acid has the following structure: Valproic acid (pKa 4.8) has a molecular weight of 144 and occurs as a colorless liquid with a characteristic odor. It is slightly soluble in water (1.3 mg/mL) and very soluble in organic solvents. Valproic Acid Capsules are antiepileptics for oral ...
Valproic acid (Advanced Reading) Valproate Injection Valproic Acid Capsules Valproic Acid Liquid Other brands Valproate Sodium, Depakene, Depacon, Stavzor Professional resources Valproic Acid monograph Valproate (FDA) Valproic Acid Capsules (FDA) Valproic Acid Oral Solution (FDA) Valproic Acid Syrup (FDA...
Valproic acid is a carboxylic acid designated as 2–propylpentanoic acid. It is also known as dipropylacetic acid. Valproic acid (pKa 4.8) has a molecular weight of 144 and occurs as a colorless liquid with a characteristic odor. It is slightly soluble in water (1.3 mg/ml) and very solu...
valproic acidmicro sampling strategydried plasma spottherapeutic drug monitoringLC‐MS/MSValproic acid (VPA) dosing needs to individualized for epilepsy patients through therapeutic drug monitoring (TDM). The patients must show up in the clinic at the therapeutic window time to venipuncture sample. ...
Simple, rapid procedure for the determination of valproate and ethosuximide in plasma by gas-liquid chromatography. Valproic AcidEthosuximideChromatography, GasGrgurinovich N, Miners JO.doi:10.1016/S0378-4347(00)81629-1N GrgurinovichJ.O. Miners... N Grgurinovich,JO Miners - 《Journal of Chr...
valproic acid Capsules (delayed-release): 125 mg, 250 mg, 500 mg Capsules (liquid-filled): 250 mg divalproex sodium Capsules (containing coated particles or sprinkles): 125 mg Tablets (enteric-coated, delayed-release): 125 mg, 250 mg, 500 mg Tablets (extended-release): 250 mg, 500 mg ...
Plasma drug concentrations were measured with reversed phase high-performance liquid chromatography (HPLC) and concentration-time data were analyzed by using a non-compartmental approach. The results of this study suggested a significant genotypic as well as allelic association with valproic acid toxicity...
valproic acidValproic acid (VPA) dosing needs to be individualized for epilepsy patients through therapeutic drug monitoring (TDM). The patients must show up in the clinic at the therapeutic window time to venipuncture sample. Dried plasma spot (DPS) sampling is an alternative way to replace ...
Serum concentrations of valproic acid were measured using the ultra-high performance liquid chromatography method with mass-spectrometric detection. The CYP2C19 (CYP2C19*2 G681A rs4244285 and CYP2C19*3 G636A rs4986893) genotypes were identified by real-time PCR analyses. The mean concentration/dose ...
Serum concentrations of valproic acid were measured using the ultra-high performance liquid chromatography method with mass-spectrometric detection. The(rs4244285 andrs4986893) genotypes were identified by real-time PCR analyses. The mean concentration/dose ratios of valproic acid were significantly higher...